肝脏缺血再灌注损伤治疗的新靶点

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.12.017

Ling Li, Binyao Chen, Huijia Zhao, Z. Fan, G. Sun, L. Dong, Jiang Yue, Q. Ye

{"title":"肝脏缺血再灌注损伤治疗的新靶点","authors":"Ling Li, Binyao Chen, Huijia Zhao, Z. Fan, G. Sun, L. Dong, Jiang Yue, Q. Ye","doi":"10.3760/CMA.J.ISSN.1007-8118.2019.12.017","DOIUrl":null,"url":null,"abstract":"Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It’s important to study the targets towards liver IRI for preventing and mitigating the clinical renal injury. It has been reported that the peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI by targeting family with sequence similarity 3 member A (FAM3A). At the meantime, noncoding RNAs, including lncRNAs and miRNAs, have also been reported to play important roles on the process of hepatic IRI. This review briefly discussed the roles and mechanisms of PPARγ, FAM3A and noncoding RNAs in liver IRI, to find potential targets of gene therapy, aiming to prevent and mitigate the liver IRI as well as to improve postoperative liver function. \n \n \nKey words: \nReperfusion injury; Liver; Noncoding RNA; Therapy","PeriodicalId":10021,"journal":{"name":"中华肝胆外科杂志","volume":"25 1","pages":"948-951"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel targets for ischemia reperfusion injury therapy in the liver\",\"authors\":\"Ling Li, Binyao Chen, Huijia Zhao, Z. Fan, G. Sun, L. Dong, Jiang Yue, Q. Ye\",\"doi\":\"10.3760/CMA.J.ISSN.1007-8118.2019.12.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It’s important to study the targets towards liver IRI for preventing and mitigating the clinical renal injury. It has been reported that the peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI by targeting family with sequence similarity 3 member A (FAM3A). At the meantime, noncoding RNAs, including lncRNAs and miRNAs, have also been reported to play important roles on the process of hepatic IRI. This review briefly discussed the roles and mechanisms of PPARγ, FAM3A and noncoding RNAs in liver IRI, to find potential targets of gene therapy, aiming to prevent and mitigate the liver IRI as well as to improve postoperative liver function. \\n \\n \\nKey words: \\nReperfusion injury; Liver; Noncoding RNA; Therapy\",\"PeriodicalId\":10021,\"journal\":{\"name\":\"中华肝胆外科杂志\",\"volume\":\"25 1\",\"pages\":\"948-951\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华肝胆外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2019.12.017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华肝胆外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2019.12.017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

肝缺血再灌注损伤(IRI)是失血性休克、肝移植和其他肝脏手术的主要并发症。研究肝脏IRI的靶点对预防和减轻临床肾损伤具有重要意义。据报道，过氧化物酶体增殖物激活受体γ (PPARγ)通过靶向序列相似家族3成员A (FAM3A)来保护肝脏免受IRI。同时，包括lncrna和mirna在内的非编码rna也被报道在肝脏IRI过程中发挥重要作用。本文就PPARγ、FAM3A和非编码rna在肝脏IRI中的作用及机制进行综述，旨在寻找基因治疗的潜在靶点，以预防和减轻肝脏IRI，改善术后肝功能。关键词:再灌注损伤;肝;非编码RNA;治疗

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Novel targets for ischemia reperfusion injury therapy in the liver

Liver ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver transplantation, and other liver surgeries. It’s important to study the targets towards liver IRI for preventing and mitigating the clinical renal injury. It has been reported that the peroxisome proliferator activated receptor gamma (PPARγ) protects the liver against IRI by targeting family with sequence similarity 3 member A (FAM3A). At the meantime, noncoding RNAs, including lncRNAs and miRNAs, have also been reported to play important roles on the process of hepatic IRI. This review briefly discussed the roles and mechanisms of PPARγ, FAM3A and noncoding RNAs in liver IRI, to find potential targets of gene therapy, aiming to prevent and mitigate the liver IRI as well as to improve postoperative liver function. Key words: Reperfusion injury; Liver; Noncoding RNA; Therapy

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.