疏水改性壳聚糖胶束形成的乳化参数研究

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2021-09-30 DOI:10.15259/pcacd.26.016

A. Piegat, A. Niemczyk, Agata Goszczyńska

{"title":"疏水改性壳聚糖胶束形成的乳化参数研究","authors":"A. Piegat, A. Niemczyk, Agata Goszczyńska","doi":"10.15259/pcacd.26.016","DOIUrl":null,"url":null,"abstract":"A series of N,O-acylated chitosan derivatives were emulsified with different fatty acids. Hydrophobically modified chitosan derivatives were expected to exhibit self-assembly behaviour resulting in micelle formation. Several parameters of the oil-in-water emulsification process were investigated: mixing method, speed and duration, volume oil phase and addition of modifiers. Their influence on micellar Z-average diameter, size distribution and Zeta potential was analysed based on dynamic light scattering measurements. There were various relations between the hydrodynamic behaviour of chitosan derivatives, their chemical structure and the process parameters. Additionally, the obtained micelles could serve as active compound carriers because they encapsulated two model substances, namely ibuprofen and α-tocopherol.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"EMULSIFICATION PARAMETERS STUDY ON MICELLES FORMATION FROM HYDROPHOBICALLY MODIFIED CHITOSAN\",\"authors\":\"A. Piegat, A. Niemczyk, Agata Goszczyńska\",\"doi\":\"10.15259/pcacd.26.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A series of N,O-acylated chitosan derivatives were emulsified with different fatty acids. Hydrophobically modified chitosan derivatives were expected to exhibit self-assembly behaviour resulting in micelle formation. Several parameters of the oil-in-water emulsification process were investigated: mixing method, speed and duration, volume oil phase and addition of modifiers. Their influence on micellar Z-average diameter, size distribution and Zeta potential was analysed based on dynamic light scattering measurements. There were various relations between the hydrodynamic behaviour of chitosan derivatives, their chemical structure and the process parameters. Additionally, the obtained micelles could serve as active compound carriers because they encapsulated two model substances, namely ibuprofen and α-tocopherol.\",\"PeriodicalId\":44461,\"journal\":{\"name\":\"Progress on Chemistry and Application of Chitin and its Derivatives\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress on Chemistry and Application of Chitin and its Derivatives\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15259/pcacd.26.016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress on Chemistry and Application of Chitin and its Derivatives","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15259/pcacd.26.016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 2

摘要

用不同的脂肪酸对一系列N，O-酰化壳聚糖衍生物进行乳化。疏水改性的壳聚糖衍生物有望表现出自组装行为，从而形成胶束。研究了水包油乳化过程中的几个参数：混合方法、速度和持续时间、油相体积和改性剂的添加。基于动态光散射测量，分析了它们对胶束Z平均直径、尺寸分布和Zeta电位的影响。壳聚糖衍生物的水动力学行为与其化学结构和工艺参数之间存在多种关系。此外，所获得的胶束可以作为活性化合物载体，因为它们包封了两种模型物质，即布洛芬和α-生育酚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

EMULSIFICATION PARAMETERS STUDY ON MICELLES FORMATION FROM HYDROPHOBICALLY MODIFIED CHITOSAN

A series of N,O-acylated chitosan derivatives were emulsified with different fatty acids. Hydrophobically modified chitosan derivatives were expected to exhibit self-assembly behaviour resulting in micelle formation. Several parameters of the oil-in-water emulsification process were investigated: mixing method, speed and duration, volume oil phase and addition of modifiers. Their influence on micellar Z-average diameter, size distribution and Zeta potential was analysed based on dynamic light scattering measurements. There were various relations between the hydrodynamic behaviour of chitosan derivatives, their chemical structure and the process parameters. Additionally, the obtained micelles could serve as active compound carriers because they encapsulated two model substances, namely ibuprofen and α-tocopherol.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.