假上皮瘤样增生:潜在鳞状细胞癌的先兆——经验教训

S. Krishnamoorthy, H. Sekar, L. Joseph, J. Kumar
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引用次数: 0

摘要

假上皮瘤样增生(PEH)是一种良性疾病,其特征是对创伤、感染、持续炎症和肿瘤等各种损伤的反应性上皮增殖。在本报告中,我们讨论了一个35岁的男性病例,他出现会阴肿胀,后来变成了无法愈合的溃疡,最初被诊断为PEH。尽管如此,在临床怀疑后,进行了更深入的活检,确认了鳞状细胞癌的诊断,并指导了适当的治疗。不愈合的会阴病变并不罕见。大多数病变原来是鳞状细胞癌。但是,如果组织病理学图片显示假上皮瘤样增生,那么考虑活检的局限性是至关重要的,并且需要可靠的临床病理相关性来积极寻找潜在的鳞状细胞癌。由于PEH的良性性质,大多数病例通过切除活检进行治疗,而偶尔需要移植物或皮瓣来修复严重的组织缺陷。因此,排除这种情况并将其与其他良性和恶性疾病区分开来至关重要,因为治疗和预后差异很大。对病变基底进行采样、分析多个切片并考虑临床数据以确保准确诊断至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt
Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling, later turned into a non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, a deeper biopsy was conducted, confirming the diagnosis of squamous cell carcinoma and directing treatment appropriately. Non-healing perineal lesions are not uncommon. Most of the lesions turn out to be Squamous Cell Carcinoma. But, if the histopathological picture suggests Pseudoepitheliomatous Hyperplasia, it is vital to consider the limitations of the biopsy, and a solid clinicopathological correlation is required to look aggressively for underlying Squamous Cell Carcinoma. Due to the benign nature of PEH, most cases are treated via excision biopsy, while grafts or flaps are occasionally required to restore severe tissue defects. It is therefore crucial to rule out and distinguish this condition from other benign and malignant conditions, as the treatment and prognosis differ widely. It is of utmost importance to sample the base of the lesion, analyze multiple sections, and consider clinical data to ensure an accurate diagnosis.
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