硒对成人危重症患者的抗氧化作用

Pub Date : 2023-07-01 DOI:10.1097/TIN.0000000000000326

M. Hasani, Fahimeh Agh, P. Irandoost, F. Farsi, A. Khodabakhshi, J. Heshmati, A. B. Pizarro, Vahideh Aghamohamadi, M. Khazdouz

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引用次数: 0

摘要

氧化应激是炎症和器官衰竭的基本病因，其不良后果是危重疾病的特征。我们系统地检索了截至2021年9月的相关随机对照试验(rct)，这些试验研究了硒对危重患者抗氧化标志物的影响。共纳入10项随机对照试验。结果表明，硒对谷胱甘肽过氧化物酶活性(标准化平均差[SMD]: 1.67, 95%可信区间[CI]:−0.01 ~ 3.35)和c反应蛋白水平(SMD:−0.21 mg/L, 95% CI:−0.45 ~ 0.03)无显著影响。需要进一步的试验来证明硒对抗氧化和炎症标志物的潜在影响。

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Antioxidant Effects of Selenium in Adult Critically Ill Patients

Oxidative stress is the fundamental etiology of inflammation and organ failure, and unfavorable consequences characterize critical illness. We searched systematically up to September 2021 to find related randomized controlled trials (RCTs) that investigated the effects of selenium in antioxidant markers of the critically ill. A total of 10 RCTs were included. The results indicated that selenium administration has no significant effects on glutathione peroxidase activity (standardized mean difference [SMD]: 1.67, 95% confidence interval [CI]: −0.01 to 3.35) and C-reactive protein levels (SMD: −0.21 mg/L, 95% CI: −0.45 to 0.03). Further trials are needed to prove the potential effects of selenium administration on antioxidant and inflammation markers.

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