葡萄糖水平与乳腺癌标志物相关

R. Das, S. Karmakar, Ishita Saha, R. Sahoo, S. K. Medda, R. Kottapalli
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引用次数: 1

摘要

本文采用概率模型,对64名癌症妇女和52名正常妇女的真实数据集以及10个感兴趣的研究因素进行了调查,重点研究了葡萄糖水平与乳腺癌生物标志物的联系。由此得出,不列颠哥伦比亚省妇女的平均血糖水平高于正常水平(P=0.02224)。平均血糖水平与胰岛素(P<0.00001)、瘦素和脂联素的相互作用(瘦素*脂联素)(P=0.08834)、稳态模型评估评分胰岛素抵抗(HOMA-IR)和瘦素(HOMA-IR*瘦素)呈负相关(P<.00001),葡萄糖水平的变化与瘦素(P=0.00022)、胰岛素(P=0.01365)、单核细胞趋化蛋白-1(MCP-1)(P=0.001153)、胰岛素*HOMA-IR(P=0.00021)、年龄*抵抗素(P=0.003974)、年龄*HOMA-IR(P=0.003102)呈负相关,抵抗素(P=0.02182)和年龄(P=0.00313)。BC女性的血糖水平较高,并且随着HOMA-IR、瘦素水平的升高和胰岛素、HOMA-IR*瘦素、瘦素*脂联素水平的降低而升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The glucose level linkages with breast cancer markers
The glucose level linkages with breast cancer (BC) biomarkers are focused in the article adopting probabilistic modeling with a real data set surveyed from 64 BC women and 52 normal women along with 10 interested study factors. It is derived that mean glucose levels are over for BC women (P=0.02224) than normal. Mean glucose levels are inversely linked with insulin (P< 0.00001), interaction effects of leptin and adiponectin (leptin*adiponectin) (P=0.08834), homeostasis model assessment score insulin resistance (HOMA-IR) and leptin (HOMA-IR*leptin) (P<0.00001), while they are directly linked with HOMA-IR (P<0.00001) and leptin (P<0.00001). The variance of glucose levels is inversely linked with leptin (P=0.00022), insulin (P=0.01365), monocyte chemoattractant protein-1 (MCP-1) (P=0.01153), insulin*HOMA-IR (P=0.00022), age*resistin (P=0.03974), age*HOMA-IR(P=0.03102), while it is directly linked with HOMA-IR (P<0.00001), resistin (P=0.02182) and age (P=0.00133). Glucose levels are higher for BC women, and they increase along with the increased levels of HOMA-IR, leptin, and the decreased levels of insulin, HOMA-IR*leptin, leptin*adiponectin.
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