{"title":"关节软骨:损伤、修复和保存","authors":"Constance R. Chu","doi":"10.1016/j.oto.2022.100964","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span><span>Freddie H. Fu, MD was a transformational advocate and leader in orthopedic<span> surgery, sports medicine, and musculoskeletal research. He also respected, nurtured, and participated in </span></span>articular cartilage research. A lot of what we know about articular cartilage stems from studies led by orthopedic faculty at the University of Pittsburgh. These contributions include pioneering work on articular cartilage metabolism and the effects of corticosteroids, the chondrotoxicity of </span>local anesthetics, and </span>chondrocyte<span> transplantation for articular cartilage repair. As department chair, Freddie Fu's tremendous leadership created conditions where new concepts and approaches advanced by orthopedic faculty such as advanced </span></span>tissue engineering<span> to create osteochondral tissues for space and drug<span> development, localized gene therapy, novel cartilage imaging, as well as the definition and demonstration of pre-osteoarthritis to prevent or delay the onset of osteoarthritis<span> are now poised to transform the future of joint preservation and musculoskeletal health.</span></span></span></p></div>","PeriodicalId":45242,"journal":{"name":"Operative Techniques in Orthopaedics","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Articular Cartilage: Injury, Restoration, and Preservation\",\"authors\":\"Constance R. Chu\",\"doi\":\"10.1016/j.oto.2022.100964\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span><span>Freddie H. Fu, MD was a transformational advocate and leader in orthopedic<span> surgery, sports medicine, and musculoskeletal research. He also respected, nurtured, and participated in </span></span>articular cartilage research. A lot of what we know about articular cartilage stems from studies led by orthopedic faculty at the University of Pittsburgh. These contributions include pioneering work on articular cartilage metabolism and the effects of corticosteroids, the chondrotoxicity of </span>local anesthetics, and </span>chondrocyte<span> transplantation for articular cartilage repair. As department chair, Freddie Fu's tremendous leadership created conditions where new concepts and approaches advanced by orthopedic faculty such as advanced </span></span>tissue engineering<span> to create osteochondral tissues for space and drug<span> development, localized gene therapy, novel cartilage imaging, as well as the definition and demonstration of pre-osteoarthritis to prevent or delay the onset of osteoarthritis<span> are now poised to transform the future of joint preservation and musculoskeletal health.</span></span></span></p></div>\",\"PeriodicalId\":45242,\"journal\":{\"name\":\"Operative Techniques in Orthopaedics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Operative Techniques in Orthopaedics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1048666622000234\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Operative Techniques in Orthopaedics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1048666622000234","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
引用次数: 0
摘要
Freddie H. Fu,医学博士是整形外科、运动医学和肌肉骨骼研究的转型倡导者和领导者。他还尊重、培养并参与了关节软骨的研究。我们对关节软骨的了解大多来自于匹兹堡大学骨科学院领导的研究。这些贡献包括关节软骨代谢和皮质类固醇作用的开创性工作,局部麻醉剂的软骨毒性,以及关节软骨修复的软骨细胞移植。作为系主任,弗雷迪·傅的卓越领导能力为骨科院系的新概念和新方法的发展创造了条件,如为空间和药物开发创造骨软骨组织的先进组织工程,局部基因治疗,新型软骨成像,以及预防或延缓骨关节炎发病的前骨关节炎的定义和演示,现在准备好改变关节保护和肌肉骨骼健康的未来。
Articular Cartilage: Injury, Restoration, and Preservation
Freddie H. Fu, MD was a transformational advocate and leader in orthopedic surgery, sports medicine, and musculoskeletal research. He also respected, nurtured, and participated in articular cartilage research. A lot of what we know about articular cartilage stems from studies led by orthopedic faculty at the University of Pittsburgh. These contributions include pioneering work on articular cartilage metabolism and the effects of corticosteroids, the chondrotoxicity of local anesthetics, and chondrocyte transplantation for articular cartilage repair. As department chair, Freddie Fu's tremendous leadership created conditions where new concepts and approaches advanced by orthopedic faculty such as advanced tissue engineering to create osteochondral tissues for space and drug development, localized gene therapy, novel cartilage imaging, as well as the definition and demonstration of pre-osteoarthritis to prevent or delay the onset of osteoarthritis are now poised to transform the future of joint preservation and musculoskeletal health.
期刊介绍:
Operative Techniques in Orthopaedics is an innovative, richly illustrated resource that keeps practitioners informed of significant advances in all areas of surgical management. Each issue of this atlas-style journal explores a single topic, often offering alternate approaches to the same procedure. Its current, definitive information keeps readers in the forefront of their specialty.