猴痘变异体全蛋白质组的结构预测

Liangzhen Zheng, Jintao Meng, Ming-cheng Lin, Rui Lv, Hongjun Cheng, Lixin Zou, Jinyuan Sun, Linxian Li, R. Ren, Sheng Wang
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引用次数: 11

摘要

最近,猴痘病毒已开始在全球许多国家传播[1]。导致当前疫情爆发的猴痘病毒变种的基因组序列已被报道,从而为更好地了解新变种、加快疫苗和药物开发提供了重要资源。在这里,我们报道了三种猴痘变体的整个蛋白质组的结构预测,并对蛋白质的潜在小分子结合区进行了注释。通过结构比对算法对实验确定的与猴痘蛋白具有高度相似性的结构进行审查。我们的工作应该有助于加快疫苗和药物的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structure prediction of the entire proteome of monkeypox variants
Recently, the monkeypox virus has begun to spread in many countries worldwide [1]. The genome sequence of the monkeypox virus variant responsible for the current outbreak has been reported, thus providing an important resource for better understanding the new variant and accelerating vaccine and drug development. Here, we report structure predictions of the whole proteomes of three monkeypox variants, with annotation of potential small-molecule-binding regions of the proteins. Experimentally determined structures with high similarity to monkeypox proteins were vetted through a structure-alignment algorithm. Our work should help accelerate the development of vaccines and drugs.
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