类风湿关节炎相关ILD的基本原理和方案:高风险患者的筛查和评估(RAISE)研究

S. C. Chan, W. Yeung, C. Cheung, W. Kwok, Leo Tsz Long Chan, C. Ho
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引用次数: 0

摘要

类风湿性关节炎(RA)是一种慢性炎症性关节疾病,患病率高达1%。各种关节外表现已被报道,包括类风湿关节炎相关间质性肺疾病(RA-ILD)。RA- ild的发病率很高,是RA患者死亡的主要原因。因此,检测肺部受累非常重要。然而,RA-ILD的患病率尚不清楚,并且根据不同的检测方法在不同的研究中有所不同。多种临床危险因素和新的生物标志物已被探索。为了评估这些预测因子的有用性和评估间质性肺疾病(ILD)在RA患者中的负担,我们设计了一项研究(RAISE,类风湿关节炎相关ILD:高风险患者的筛查和评估),以评估RA-ILD在高风险RA患者中的患病率,并确定与该疾病相关的潜在临床和生化标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rationale and the Protocol for the Rheumatoid Arthritis-Associated ILD: Screening and Evaluation in High-Risk Patients (RAISE) Study
Rheumatoid arthritis (RA) is chronic inflammatory joint disease with a prevalence of up to 1%. Various extra-articular manifestations have been reported, including rheumatoid arthritis-associated interstitial lung disease (RA-ILD). RA-ILD contributes to significant morbidity and is a leading cause of death in patients with RA. Detection of lung involvement is therefore important. However, the prevalence of RA-ILD is not well known and varies among different studies depending on the methods of detection. Multiple clinical risk factors and novel biomarkers have been explored. To evaluate the usefulness of these predictors and to evaluate the burden of interstitial lung disease (ILD) among patients with RA, we designed a study (RAISE, Rheumatoid Arthritis-associated ILD: Screening and Evaluation in high-risk patients) to assess the prevalence of RA-ILD among RA patients with high risk, and to identify potential clinical and biochemical markers associated with the condition.
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