鼻咽癌IMRT (SS / SW)和VMAT治疗方案的剂量学评价

Q3 Health Professions
Rachid Errifai, Youssef Bouzekraoui, F. Bentayeb
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引用次数: 0

摘要

由于靶体积周围存在复杂的几何形状和非常敏感的器官,球形ORL的放疗仍然很困难。这种武器得益于2009年推出的VMAT(体积调制电弧治疗)技术的进步,它结合了动态电弧治疗技术的优势和固定光束强度调制(RCMI)的构象放疗技术的优势。材料与方法:比较4例患者的治疗方案,分别采用SS、SW、VMAT (6MV x射线束)进行治疗。目标卷有三个:PTV 70、PTV 63和PTV56。所描述的危险器官为脊髓、脑干和腮腺。剂量以综合增强(SIB)方式每天一次,每周5天,分35次给药,旨在将规定剂量递送到肿瘤体积,同时尊重危险器官的剂量限制,并将其毒性程度降至最低。结果:靶体积覆盖率(Dmax)也有类似的结果。SS技术允许更好地保留腮腺,这解释了它对限制晚期并发症(如口干症)的贡献。VMAT技术可以通过减少约6 Gy来更好地保护脑干,对于脊髓,所接受的剂量几乎相等。最后,不同技术之间没有统计学上的显著差异。结论:从剂量学和临床的角度来看,所有这些结果都符合这些创新技术的构象能力。它们能够覆盖目标体积,同时在很大程度上尊重危险器官的限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dosimetric evaluation of IMRT (SS / SW) and VMAT treatment plans for nasopharyngeal cancer
Introduction: Radiotherapy of the sphere ORL is still difficult by the presence of complex geometries and very sensitive organs around the target volume.This weapon has benefited from the advances of the VMAT (Volumetric Modulated Arc Therapy) technique, introduced in 2009, it combines the advantages of dynamic arc therapy techniques with the advantages of conformational radiotherapy techniques with intensity modulation (RCMI) by stationary beams.Materials and Methods: The treatment plans of the 4 patients were compared and treated with SS, SW, and VMAT (6MV X-ray beam). The target volumes were three: PTV 70, PTV 63, and PTV56. The organs at risk delineated were the spinal cord, the brainstem, the parotid gland .The dose was delivered once a day, five days a week and in 35 sessions in Integrated Boost (Simultaneaous Integrated Boost (SIB)), aiming to deliver the prescribed dose to the tumor volume while respecting the dose constraints in the organs at risk and minimizing their degree of toxicity.Results: Similar results were found for target volume coverage (Dmax). The SS technique allowed better parotid sparing, which explains its contribution to limiting late complications such as xerostomia. The VMAT technique allows better protection of the brainstem by reducing about 6 Gy, for the spinal cord the doses received were almost equal. Finally, there is no statistically significant difference between the different techniques.Conclusion: All these results conform the conformational capacities of these innovative techniques from a dosimetric and above all clinical point of view. Their ability to cover the target volumes while largely respecting the constraints on organs at risk.
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来源期刊
Iranian Journal of Medical Physics
Iranian Journal of Medical Physics Health Professions-Radiological and Ultrasound Technology
CiteScore
1.00
自引率
0.00%
发文量
0
审稿时长
8 weeks
期刊介绍: Iranian Journal of Medical Physics (IJMP) is the official scientific bimonthly publication of the Iranian Association of Medical Physicists. IJMP is an international and multidisciplinary journal, peer review, free of charge publication and open access. This journal devoted to publish Original Papers, Review Articles, Short Communications, Technical Notes, Editorial and Letters to the Editor in the field of “Medical Physics” involving both basic and clinical research. Submissions of manuscript from all countries are welcome and will be reviewed by at least two expert reviewers.
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