人表皮生长因子受体2基因扩增状态与乳腺癌临床病理特征的关系

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-02-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.02.007

Tiantian Zhao

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引用次数: 0

摘要

目的探讨人表皮生长因子受体2（HER2）基因扩增状况与癌症临床病理特征的关系，分析癌症腋窝淋巴结转移的影响因素。方法收集2016年1月至2019年3月滕州市中心人民医院收治的262例癌症患者的临床病理资料，包括年龄、肿瘤直径、组织学分级、病理类型、淋巴结转移、肿瘤数目、肿瘤位置。患者进行常规病理检查，HER2免疫组织化学（IHC）结果为++。IHC法检测p53、Ki-67、雌激素受体（ER）、孕激素受体（PR）的表达。通过荧光原位杂交（FISH）检测HER2的基因扩增状态。分别分析HER2基因扩增状态与临床病理特征的关系、腋窝淋巴结转移与临床病理特点的关系。结果262例癌症患者中有69例检测到HER2基因扩增阳性，阳性扩增率为26.3%，HER2基因的扩增状态与Ki-67增殖指数、ER和PR的表达相关，差异有统计学意义（X2=13.27，P＜0.05），腋窝淋巴结转移106例（40.5%）。结论癌症HER2基因扩增与Ki-67增殖指数、ER和PR的表达有关，肿瘤直径是影响腋窝淋巴结转移的一个因素。准确判断上述指标可以更好地指导癌症的治疗和预后评估。关键词：乳腺肿瘤；人表皮生长因子受体2；基因扩增；淋巴结转移；病理学，临床

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Relationship between gene amplification status of human epidermal growth factor receptor 2 and clinicopathological features in breast cancer

Objective To explore the relationship between gene amplification status of human epidermal growth factor receptor 2 (HER2) and its clinicopathological features in breast cancer, and to analyze the affecting factors of axillary lymph node metastasis in breast cancer. Methods The clinicopathological data of 262 patients with breast cancer at Tengzhou Central People's Hospital between January 2016 and March 2019 were collected, including age, tumor diameter, histological grade, pathological type, lymph node metastasis, tumor number, tumor location. The patients had routine pathology examination and the immunohistochemistry (IHC) result of HER2 was ++. The expressions of p53, Ki-67, estrogen receptor (ER), progesterone receptor (PR) were detected by using IHC. The gene amplification status of HER2 was detected by using fluorescence in situ hybridization (FISH). The relationship between gene amplification status of HER2 and clinicopathological features, the relationship between axillary lymph node metastasis and clinicopathological features was respectively analyzed. Results HER2 gene amplification-positive was detected in 69 cases of 262 breast cancer patients, and the positive amplification rate was 26.3%. The gene amplification status of HER2 was correlated with Ki-67 proliferation index and the expression of ER as well as PR, and the differences were statistically significant (χ 2=13.27, P 0.05). Among 262 cases of breast cancer, 106 (40.5%) cases had axillary lymph node metastasis. Lymph node metastasis was correlated with tumor diameter (χ 2=29.10, P 0.05). Conclusions HER2 gene amplification of breast cancer is associated with Ki-67 proliferation index, the expression of ER and PR. The tumor diameter is a factor for affecting axillary lymph node metastasis. Accurate judgment of the above indicators can better guide the treatment and evaluate the prognosis of breast cancer. Key words: Breast neoplasms; Human epidermal growth factor receptor 2; Gene amplification; Lymph node metastasis; Pathology, clinical

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.