COVID-19感染艾滋病毒患者:病例系列

Q4 Medicine

HIV Infection and Immunosuppressive Disorders Pub Date : 2023-01-24 DOI:10.22328/2077-9828-2022-14-4-87-92

V. H. Fazylov, A. Oleynik, Chandrasekar G Revathy, Ah. M. Fayyadh, O. Abdullah

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引用次数: 0

摘要

本文介绍了新冠肺炎确诊病例在住院成人艾滋病毒感染者中的一系列临床观察。与普通人群中的新冠肺炎患者相比，观察到的患者组的特点是年龄较小，共病病理学不同，临床和实验室病程中等且可比，但SARS-CoV-2清除时间更长。随着继发性疾病的发展，HIV感染的晚期（p=0.08），CD4+T淋巴细胞的相对数量下降小于2%（p=0.03），CD4+/CD8+的相对数量减少小于0.05（p=0.03），巨细胞病毒感染的存在（p=0.004）区分了HIV-严重急性呼吸系统综合征冠状病毒2型共感染患者，其预后较差。注意到严重免疫缺陷患者中新冠肺炎和巨细胞病毒感染的临床和放射学过程的存在和相似性，这需要极其彻底的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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COVID-19 in patients with HIV: case-series

The article presents a series of clinical observations of confirmed cases of COVID-19 in hospitalized adult patients with HIV infection. The observed group of patients was characterized by a young age, a different spectrum of comorbid pathology, a moderate and comparable clinical and laboratory course, with the exception of a more prolonged clearance of SARS-CoV-2 compared with COVID-19 patients from the general population. Advanced stage of HIV infection with the development of secondary diseases (p=0.08), decrease in the relative number of CD4+T-lymphocytes less than 2% (p=0.03), and CD4+/CD8+ less than 0.05 (p=0.03), the presence of cytomegalovirus infection (p=0.004) distinguished HIV-SARS-CoV-2-coinfected patients with poor outcomes. The presence and similarity of the clinical and radiological course of COVID-19 and cytomegalovirus infection in patients with severe immunodeficiency was noted, which requires an extremely thorough differential diagnosis.

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来源期刊

HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.