毛囊色素干细胞在308 nm准分子激光治疗白癜风中的作用:人类病例的免疫组织化学研究

IF 1.1 Q4 ALLERGY

Journal of Cutaneous Immunology and Allergy Pub Date : 2022-09-06 DOI:10.1002/cia2.12271

Reiko Noborio MD, PhD, Yuki Nomura MD, Kahori Nakatani MD, Takahiro Kiyohara MD, PhD, Emi Nishida MD, PhD, Motoki Nakamura MD, PhD, Akimichi Morita MD, PhD

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引用次数: 0

摘要

在紫外线(UV)治疗后，白癜风的毛囊周围经常观察到色素再生，这表明存在于毛囊中的黑色素细胞库移动到表皮并分化为黑色素细胞。虽然308 nm准分子激光对白癜风有效，但色素再生的机制尚不清楚。为了研究白癜风中色素再生和色素干细胞之间的关系，我们从使用XTRAC Velocity 7™(Strata Science)治疗的患者身上获得了活检标本。免疫组化检测采用抗细胞角蛋白15(抗CK15小鼠单克隆抗体，克隆:LKH15;Gene Tex Inc.)和抗小眼转录因子(抗MITF小鼠单克隆抗体，克隆号:D5;Neomarkers)。CK15是毛囊膨出病变干细胞的标记物2,MITF是黑色素细胞谱系标记物，表达于黑色素母细胞和黑色素细胞中。本研究旨在确定准分子激光照射与凸起区MITF-阳性细胞(CK15-阳性细胞)之间的关系。凸起病变中的CK15-和MITF-阳性细胞被认为是黑素母细胞。活检标本取自一位70多岁男性患者的大腿下部，取自正常的未照射区域，取自滤泡型色素再生区域，取自治疗20次后白癜风患者的非色素再生区域。在正常样本中

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Role of pigment stem cells in hair follicles in the treatment of vitiligo with a 308-nm excimer laser: An immunohistochemical study of human cases

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Role of pigment stem cells in hair follicles in the treatment of vitiligo with a 308-nm excimer laser: An immunohistochemical study of human cases

An immunohistochemical study of human vitiligo case was performed. The excimer laser irradiation may induce the differentiation of melanoblasts and melanocytes from bulge stem cell.

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来源期刊

Journal of Cutaneous Immunology and Allergy Medicine-Dermatology

CiteScore

0.60

自引率

10.00%

发文量

审稿时长

12 weeks