{"title":"HLA-B*27在人类健康和疾病中的作用","authors":"S. Andrei, Dan Denis Boloca, O. Popa, C. Bârã","doi":"10.37897/rjr.2019.2.2","DOIUrl":null,"url":null,"abstract":"HLA-B*27 is one of the most studied HLA allele due to its association with diseases from the spondyloarthritis group, mainly ankylosing spondylitis. This association is still the strongest association described in the literature between an HLA gene and a disease. In the general population, the distribution of HLA-B*27 all over the world seems to vary according to the geographic area of the country. It also has a protective role against certain conditions, especially viral infections.","PeriodicalId":33518,"journal":{"name":"Revista Romana de Reumatologie","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HLA-B*27 in human health and disease\",\"authors\":\"S. Andrei, Dan Denis Boloca, O. Popa, C. Bârã\",\"doi\":\"10.37897/rjr.2019.2.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"HLA-B*27 is one of the most studied HLA allele due to its association with diseases from the spondyloarthritis group, mainly ankylosing spondylitis. This association is still the strongest association described in the literature between an HLA gene and a disease. In the general population, the distribution of HLA-B*27 all over the world seems to vary according to the geographic area of the country. It also has a protective role against certain conditions, especially viral infections.\",\"PeriodicalId\":33518,\"journal\":{\"name\":\"Revista Romana de Reumatologie\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Romana de Reumatologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37897/rjr.2019.2.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Romana de Reumatologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjr.2019.2.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
HLA- b *27是研究最多的HLA等位基因之一，因为它与脊柱炎组疾病有关，主要是强直性脊柱炎。这种关联仍然是在HLA基因和疾病之间的文献描述最强的关联。在一般人群中，HLA-B*27在世界各地的分布似乎因国家的地理区域而异。它还对某些疾病有保护作用，尤其是病毒感染。
HLA-B*27 is one of the most studied HLA allele due to its association with diseases from the spondyloarthritis group, mainly ankylosing spondylitis. This association is still the strongest association described in the literature between an HLA gene and a disease. In the general population, the distribution of HLA-B*27 all over the world seems to vary according to the geographic area of the country. It also has a protective role against certain conditions, especially viral infections.
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