失巢效应基因bcl-2转录抑制剂1的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-02-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.02.015

Jialing Liu, Linsheng Huang, Xin-hai Ye, Jie Zhou, Fei Li

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引用次数: 0

摘要

bcl-2转录抑制剂1（Bit1）是一种失巢效应物，通过下调bcl-2的表达，在caspase非依赖性细胞凋亡中发挥作用。先前的研究发现，Bit1通过Erk和FAK-PI3K-Akt-NF-κB途径影响细胞存活和凋亡。值得注意的是，Bit1的表达在不同肿瘤中表现出明显的肿瘤特异性，它与肿瘤的TNM分期、分化和预后密切相关。本文综述了Bit1在不同肿瘤中的表达、主要机制及其意义。关键词：细胞凋亡；肿瘤；Bcl-2转录抑制剂1

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Progress of the anoikis effector bcl-2 inhibitor of transcription 1

bcl-2 inhibitor of transcription 1 (Bit1) is an anoikis effector that can play a role of caspase-independent apoptosis by down-regulating bcl-2 expression. Previous studies have found that Bit1 affects cell survival and apoptosis through Erk and FAK-PI3K-Akt-NF-κB pathways. It is worth noting that the expression of Bit1 has shown the obvious tumor specificity in different tumors, and it is closely related to TNM stage, differentiation and prognosis of the tumor. This review summarizes the expression, main mechanism, and significance of Bit1 in different tumors. Key words: Apoptosis; Neoplasms; Bcl-2 inhibitor of transcription 1

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.