Age-Related Menopause and Carbonyl Stress

The review analyzes the published data of some studies on redox homeostasis in women with age-related physiological menopause. Despite the ambiguity of the presented results on the oxidative modification of lipids, proteins, and carbohydrates, most studies allow us to consider this age period as one of the factors in the development of carbonyl stress, which is an integral part of aging. The presence of hyperglycemia and free-radical pathology are presented as the main causes of the development of carbonyl stress; age-related deficiency of estrogens, taking into account their antioxidant properties, is considered as one of the triggers for the development of this condition, and the glutathione system is defined as one of its main inhibitors.