胆管癌骨显像阳性的相关因素

Q4 Medicine
Nattawat Siurai, Prin Twinprai, D. Theerakulpisut, J. Chindaprasirt, Y. Raruenrom
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引用次数: 0

摘要

目的:探讨胆管癌(CCA)患者骨显像(BS)阳性的相关因素,以帮助评估胆管癌患者对BS的合理利用。材料和方法:本横断面研究纳入了2012年1月至2020年7月期间接受BS治疗的CCA患者,以检测骨转移。由两名核医学医师检查BS图像以评估BS阳性。评估因素包括肿瘤位置、T分期、局部淋巴结转移、其他远处转移、血清碳水化合物抗原19-9 (CA19-9)。使用双变量和多元逻辑回归分析协变量与阳性BS之间的关系。结果:158例CCA患者中,BS阳性70例(44.3%),阴性84例(53.2%),模棱两可4例(2.5%)。在所有70例阳性病例中,50例(71.4%)有多发性转移灶。脊柱是最常见的转移部位(n=55, 78.6%)。在排除模棱两可的病例后,154例纳入回归模型。在双变量logistic回归中,与BS阳性相关的因素为肝内肿瘤位置(OR=2.18, p值=0.039)和其他远处转移(OR=2.08, p值=0.028)。进一步的多元逻辑回归分析显示,只有其他远处转移与BS阳性相关(OR=2.66, p值=0.008)。结论:CCA患者其他远处转移与BS阳性有显著相关性。这一因素应被视为这组患者要求BS的临床指征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors Associated with Bone Scintigraphy Positivity in Cholangiocarcinoma
Objective: To examine factors associated with bone scintigraphy (BS) positivity in cases with cholangiocarcinoma (CCA) to help assess appropriate utilization of BS in CCA patients. Material and Methods: This cross-sectional study enrolled CCA patients who underwent BS for detection of bone metastasis between January 2012 and July 2020. The BS images were reviewed by two nuclear medicine physicians to assess BS positivity. Factors including tumor location, T stage, regional lymph node metastasis, other distant metastases, and serum carbohydrate antigen 19-9 (CA19-9) were evaluated. Associations between covariates and positive BS were analyzed using bivariate and multiple logistic regressions. Results: Among 158 CCA patients, 70 (44.3%), 84 (53.2%), and 4 (2.5%) had positive, negative, and equivocal BS, respectively. Of all 70 positive cases, 50 cases (71.4%) had multiple metastatic lesions. The spine was the most common metastatic site (n=55, 78.6%). After exclusion of equivocal cases, 154 were included in the regression models. In bivariate logistic regression, the factors associated with BS positivity were intrahepatic tumor location (OR=2.18, p-value=0.039) and other distant metastasis (OR=2.08, p-value=0.028). Further analysis using multiple logistic regression showed only other distant metastasis was associated with positive BS (OR=2.66, p-value=0.008). Conclusion: There was a significant association between other distant metastasis and BS positivity in CCA patients. This factor should be considered as a clinical indication for requesting BS in this group of patients.
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CiteScore
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