纵向研究的统计分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-10-17 DOI:10.1111/insr.12523

Nan M. Laird

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引用次数: 2

摘要

纵向研究在研究个人的成长、变化和/或衰退，以及描述影响变化的环境和社会因素方面发挥着突出作用。纵向研究的基本特征是在多个时间点对同一组个体的结果进行重复测量，从而允许研究者在测量期间描述受试者内部的变化。本文概述了纵向研究的基本设计特征和分析与其他研究设计的关系，包括纵向临床试验和重复测量研究。我总结了在Laird和Ware中描述的线性混合模型的使用，用于分析一类广泛的设计，并提出了一些在健康和医学方面的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Statistical analysis of longitudinal studies

Longitudinal studies play a prominent role in research on growth, change and/or decline in individuals, and in characterising the environmental and social factors which influence change. The essential feature of a longitudinal study is taking repeated measures of an outcome on the same set of individuals at multiple timepoints, thereby allowing investigators to characterise within subject changes during the measurement period. This paper provides an overview of how the basic design features and analysis of longitudinal studies are related to other study designs, including longitudinal clinical trials as well as repeated measures studies. I summarise the use of the linear mixed model as described in Laird and Ware for the analysis of a broad class of designs and present some applications in health and medicine.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.