不同温度下酮康唑在乙二醇+水混合物中的溶解度

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY

Moscow University Chemistry Bulletin Pub Date : 2023-06-07 DOI:10.3103/S0027131423030094

Homa Rezaei, Abolghasem Jouyban, Fleming Martinez, Elaheh Rahimpour

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引用次数: 1

摘要

在293.2 ~ 313.2 K的温度下，用摇瓶法测定了酮康唑在乙二醇二元水溶液中的溶解度分布，并用van ' t Hoff、λh方程、Yalkowsky、Jouyban-Acree和Jouyban-Acree - van ' t Hoff模型进行了数学表示，并用平均相对偏差表示了模型的性能。确定了酮康唑饱和溶液的密度值，并用Jouyban-Acree模型表示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Solubility of Ketoconazole in Ethylene Glycol + Water Mixtures at Different Temperatures

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Solubility of Ketoconazole in Ethylene Glycol + Water Mixtures at Different Temperatures

Solubility profile of ketoconazole in the aqueous binary mixtures of ethylene glycol is measured by a shake-flask method at 293.2–313.2 K and mathematically represented by some cosolvency models (e.g. van’t Hoff, the λh equation, the Yalkowsky, the Jouyban–Acree, and the Jouyban–Acree–van’t Hoff models) and the models’ performances are illustrated by mean relative deviations. The density values of ketoconazole saturated solutions are also determined and represented by Jouyban–Acree model.

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.