苯二氮卓类药物的使用与痴呆风险

IF 0.6 Q4 CLINICAL NEUROLOGY

Future Neurology Pub Date : 2018-11-01 DOI:10.2217/FNL-2017-0040

R. Tampi, Deena Tampi, J. Young, A. Banerjee

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引用次数: 8

摘要

新出现的证据表明，在老年人中使用苯二氮卓类药物可能会增加患痴呆症的风险。对文献的回顾确定了13项调查这一联系的研究。八项研究发现苯二氮卓类药物的使用与痴呆症的发展呈正相关。两项研究没有发现这种关联，两项结果喜忧参半，一项研究发现苯二氮卓类药物的使用降低了痴呆症的发病率。由于这些研究都不是对照前瞻性研究，因此无法确定因果关系。苯二氮卓类药物的使用与痴呆症的发展之间的联系引起了老年人的担忧。

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Benzodiazepine use and the risk for dementia

Emerging evidence indicates that the use of benzodiazepines among older adults may increase the risk of development of dementia. A review of the literature identified 13 studies investigating this link. Eight studies found a positive association between the use of benzodiazepines and development of dementia. Two studies found no such association, two had mixed results and one study found that benzodiazepine use reduced the incidence of dementia. As none of these studies were controlled prospective studies, causality could not be ascertained. The association identified between the use of benzodiazepines and the development of dementia is a cause for concern among older adults.

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来源期刊

Future Neurology CLINICAL NEUROLOGY-

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： The neurological landscape is changing rapidly. From the technological perspective, advanced molecular approaches and imaging modalities have greatly increased our understanding of neurological disease, with enhanced prospects for effective treatments in common but very serious disorders such as stroke, epilepsy, multiple sclerosis and Parkinson’s disease. Nevertheless, at the same time, the healthcare community is increasingly challenged by the rise in neurodegenerative diseases consequent upon demographic changes in developed countries.