老年人多系统萎缩伴小脑性共济失调(MSA-C)和病态窦综合征平衡问题的处理

IF 0.4 Q4 GERONTOLOGY
A. Eker, P. Yiğitoğlu, H. Duygu, E. Tan
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引用次数: 0

摘要

多系统萎缩(MSA)是一种迟发性、散发性、进行性神经退行性疾病,临床特征为自主神经功能衰竭和左旋多巴反应不良的帕金森病或小脑性共济失调。目前还没有有效的治疗方法。目前的治疗策略主要是基于多巴胺替代和自主神经衰竭的改善。氯硝西泮、心得安、巴氯芬、金刚烷胺、加巴喷丁、丁螺环酮也曾用于MSA患者共济失调的对症治疗,但其疗效一般且短暂。在此,我们描述了一位MSA-C患者,她患有致残性共济失调和病态窦综合征,在金刚烷胺治疗和心脏起搏器植入后,她的症状有明显改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of balance problems in an elderly with multiple system atrophy with predominant cerebellar ataxia (MSA-C) and sick sinus syndrome
Multiple system atrophy (MSA) is a late-onset, sporadic, progressive, neurodegenerative disorder clinically characterized by autonomic failure and either poorly levodopa-responsive parkinsonism or cerebellar ataxia. There isn’t any effective treatment on disease progression. Current therapeutic strategies are primarily based on dopamine replacement and improvement of autonomic failure. Clonazepam, propranolol, baclofen, amantadine, gabapentin, buspirone have also been used for symptomatic treatment of ataxia in MSA patients, but their efficacy known modest and transient. Herein we describe a MSA-C patient with disabling ataxia and sick sinus syndrome who showed distinct improvement in her symptoms after amantadine treatment and cardiac pacemaker implantation.
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
31
期刊介绍: The Journal of Gerontology and Geriatrics (JGG) is the official journal of the Italian Society of Gerontology and Geriatrics (SIGG), which will be an international, interdisciplinary, peer-reviewed journal concerning frontiers and advances in the field of aging. The aim of the journal is to provide a forum for original research papers, reviews, clinical case reports, and commentaries on the most relevant areas pertaining to aging. JGG publishes relevant articles covering the full range of disciplines pertaining to aging. Appropriate areas include (but are not limited to) Physiology and Pathology of Aging, Biogerontology, Epidemiology, Clinical Geriatrics, Pharmacology, Ethics, Psychology, Sociology and Geriatric Nursing.
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