边缘型人格障碍患者唾液催产素的低调节：一项自然和实验的初步研究

Psychiatry research communications Pub Date : 2023-06-01 DOI:10.1016/j.psycom.2023.100117

T. Aboulafia-Brakha , N. Perroud , D. Suchecki , R. Nicastro , K. Dieben , L. Curtis

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引用次数: 1

摘要

我们在此报告了一项主要旨在评估边缘型人格障碍(BPD)患者和健康对照者内源性催产素(OXT)分泌的试点试验。这是首次使用唾液OXT对BPD进行试验，并研究其在自然环境和实验应激任务中的反应性。与对照组相比，BPD患者在自然环境中表现出较低的OXT变化，在应激任务中表现出较低的OXT反应性，与较高的感知压力和愤怒状态形成对比。我们确认该方案的可行性。我们的结果鼓励实施更大的试验来解决具体的假设。

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Hypomodulation of salivary oxytocin in patients with borderline personality disorder: A naturalistic and experimental pilot study

We report here a pilot trial that mainly aimed to assess the endogenous secretion of oxytocin (OXT) in patients with Borderline personality disorder (BPD) and healthy controls. It is the first trial with BPD using salivary OXT and studying its reactivity in a natural setting and an experimental stress task. Compared to controls, patients with BPD showed lower variation of OXT in the natural setting and lower OXT reactivity during the stress task, contrasting to higher perceived stress and anger states. We confirm the feasibility of the protocol. Our results encourage the implementation of a larger trial to address specific hypotheses.

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来源期刊

Psychiatry research communications Psychiatry and Mental Health

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

77 days