Green Synthesis of Silver Nanoparticles: An Application of Antibiotics

The goal of this research is to use dental caries patients’ oral cavity-isolated Enterobacter aerogenes bacterial strains (S1, S2 and S3) to create silver nanoparticles (AgNPs) in an environmentally friendly and cost-effective manner. In addition, the study explores the combination of antibiotics with Streptococcus mitis MDR, which was isolated from patients with dental caries to determine their antibacterial efficiency. Clinical bacterial strains identified from dental caries patients' mouths were all resistant to standard antibiotics. Antibiotics and AgNPs have a synergistic impact, which suggests that antibiotics will make up a larger portion of the diet. It was shown that erythromycin E had the greatest synergistic impact with AgNPs (0.1 mg/ml), but Streptomycin and Tetracycline had only 6 mm inhibitory zones when paired with AgNPs (0.1 mg/ml) in comparison. Antagonizing effects are meant by this. It was revealed that antibiotics such as penicillin P and cephalexin CN had distinct effects on patients. When used in combination with antibiotics, Enterobacter aerogenes AgNPs demonstrated excellent antibacterial efficacy on Streptococcus mitis isolates. As a result, AgNPs in the dental care area have a wide range of applications.