药物引起的美沙血红蛋白血症

Q4 Medicine

Adverse Drug Reaction Bulletin Pub Date : 2019-04-01 DOI:10.1097/FAD.0000000000000040

W. Hutton, M. Pucci

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引用次数: 1

摘要

获得性美沙血红蛋白血症可由多种不同药物的氧化作用引起。引起美沙血红蛋白血症的处方药包括局部麻醉剂、氨苯砜、磺酰胺和伯氨喹。众所周知，娱乐性药物，如亚硝酸戊酯和异丁基酯（“兴奋剂”）以及可卡因中的掺杂物也会导致美沙血红蛋白血症。低浓度的血红蛋白不需要治疗，但高浓度的血红蛋白可能致命。如有需要，可选择使用甲硫茚氯化物进行治疗。更复杂的案件应该与当地的毒物中心讨论。

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Drug induced methaemoglobinaemia

Summary Acquired methaemoglobinaemia can be caused by the oxidising effect of a number of different drugs. Prescribed drugs that cause methaemoglobinaemia include local anaesthetics, dapsone, sulphonamides and primaquine. Recreational drugs such as amyl and isobutyl nitrite (‘poppers’) and adulterants in cocaine are also well known to cause methaemoglobinaemia. Low concentrations of methaemoglobin do not require treatment, but higher concentrations can be fatal. When indicated, methylthioninium chloride is the treatment of choice. More complicated cases should be discussed with a local poisons centre.

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来源期刊

Adverse Drug Reaction Bulletin Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced