评价氯胺酮静脉注射与吗啡治疗上肢/下肢长/短骨骨折疼痛的镇痛和镇静效果II期临床试验

IF 1.1 Q4 IMMUNOLOGY
H. Motamed, Meisam Moezi, Azam Khilghi, M. Fahimi
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引用次数: 0

摘要

导读:在急诊收治的肢体创伤患者及其并发症中,疼痛控制的重要性是急诊后护理的主要关注点之一,它对患者病情的加速改善具有重要意义。目的:本研究旨在评价静脉注射氯胺酮与吗啡对缓解上肢/下肢长/短骨骨折疼痛的镇痛和镇静作用。患者和方法:本研究为双盲随机临床试验。为此,在18-65岁的肢体创伤住院急诊科患者中,氯胺酮和吗啡分别以0.4和0.1 mg/kg/IV/10 min的剂量静脉注射氯胺酮和吗啡,初步检查了氯胺酮和吗啡的效果。根据视觉模拟评分(VAS)结果比较各组镇痛效果持续时间、疼痛缓解程度,以及各药物的并发症,包括呼吸暂停、心动过缓、心动过速、意识改变、恶心、呕吐、高血压/低血压、癫痫发作、睡眠障碍等,并介绍首选方法。结果:本研究共纳入120例患者,其中氯胺酮组60例,吗啡组60例。参与者的年龄范围在19 -70岁之间。患者平均年龄47.04±12.57岁,其中男性89例(74.2%)。研究结果表明,低剂量氯胺酮输注对患者疼痛的缓解作用与吗啡相当。结论:氯胺酮可作为静脉注射吗啡的替代药物,减轻上肢/下肢长/短骨骨折疼痛。试验注册:试验方案由伊朗临床试验注册中心授权,(标识符:IRCT20170716035105N3;https://en.irct.ir/trial/26628,道德准则:IR.AJUMS.REC.1396.248)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the analgesic and sedative effects of intravenous ketamine versus morphine administration on relieving long/short bone-fracture pain in the upper/ lower limbs; a phase II clinical trial
Introduction: The importance of pain control in patients with limb trauma admitted to emergency departments as well as its complications is among the main concerns in post-emergency care, which contributes to the accelerated improvement of patients’ conditions in a significant manner. Objectives: The present study was to evaluate the analgesic and sedative effects of intravenous (IV) ketamine versus morphine administration on relieving long/short bone-fracture pain in the upper/lower limbs. Patients and Methods: The present study is as a double-blind randomized clinical trial. For this purpose, the effect of ketamine and morphine were initially examined using IV ketamine and morphine administration, respectively, at the doses of 0.4 and 0.1 mg/kg/IV/10 min in patients, aged 18-65 years with limb trauma, and admitted to hospital emergency departments. Afterward, the duration of the analgesic effect, the amount of pain relief, according to the visual analog scale (VAS) outcomes, and the complications for each drug, including apnea, bradycardia, tachycardia, altered level of consciousness, nausea, vomiting, hypertension/hypotension, seizures and disturbed sleep were compared, and then the preferred method was introduced. Results: In this study, 120 patients in total, including 60 cases receiving ketamine and 60 individuals receiving morphine, were recruited. The participants’ age range was between 19 -70 years. The patients’ mean age was 47.04±12.57 years of whom 89 patients (74.2%) were male. The study results indicated that the potency of the low-dose ketamine infusion in relieving pain in patients was comparable to that of morphine. Conclusion: It was concluded that ketamine could be administered as an alternative to IV morphine to reduce long/short bone-fracture pain in the upper/lower limbs. Trial Registration: The trial protocol was authorized by the Iranian Registry of Clinical Trials, (identifier: IRCT20170716035105N3; https://en.irct.ir/trial/26628, ethical code: IR.AJUMS.REC.1396.248).
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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