氧化应激在抗结核药物相关肝毒性管理中的突出作用。

Drug metabolism letters Pub Date : 2020-01-15 DOI:10.2174/1872312813666190716155930

P. John, P. Kale

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引用次数: 3

摘要

结核病的流行率近年来有所上升，可获得先进的医疗服务和治疗方法。然而，持续服用相关药物也会导致肝毒性，这是一种不容忽视的危急情况。本文综述了引起这些毒性的途径，以及CYP2E1酶和肝谷胱甘肽作为可能靶点的作用，这些靶点有助于抑制肝毒性的持续不良反应。

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Prominence of oxidative stress in the management of Anti-tuberculosis drugs related hepatotoxicity.

Advanced medical services and treatments are available for treating Tuberculosis, whose prevalence has increased in recent times. However, the continuous consumption of related drugs is also known for inducing hepatotoxicity which is a critical condition and cannot be overlooked. The present review article has focused on the pathways causing these toxicities and also the role of enzyme CYP2E1 and hepatic glutathione as possible targets which would help inhibit the ongoing adverse effect of hepatotoxicity.

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来源期刊

Drug metabolism letters Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

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发文量

期刊介绍： Drug Metabolism Letters publishes letters and research articles on major advances in all areas of drug metabolism and disposition. The emphasis is on publishing quality papers very rapidly by taking full advantage of the Internet technology both for the submission and review of manuscripts. The journal covers the following areas: In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites.