А在滨海边疆区感染艾滋病毒的青少年中实施了人乳头瘤病毒疫苗接种试点项目

Q4 Medicine
A. Chernikov, L. F. Sklyar, O. A. Scaly, S. N. Beniova
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引用次数: 0

摘要

目的:了解普里莫尔斯基地区儿童HIV感染的流行病学特征,并分析青少年HIV感染者接种人乳头瘤病毒疫苗的结果。材料和方法。他们对感染HPV 52 HIV的青少年进行了预防。结果:接种前、接种后3个月和6个月,对CD4淋巴细胞水平和HIV病毒载量(VL)进行三次监测。在即将接种疫苗的6个月前,所有52名个体的CD4淋巴细胞水平在1毫升中为350至1925个细胞(平均值为857,5),VL在1毫升内为0至300个拷贝(平均值64,6)。在接种过程中,CD4淋巴细胞的水平趋于增加,在1毫升中为350至1952个细胞(平均值为884,1),而VL指数甚至从0降至274(平均值每1毫升53.9个拷贝)。在完成疫苗接种6个月后,所有指标实际上也没有变化:CD4淋巴细胞在1ml中的水平为353至1955个细胞(平均值为844,5),VL在0至302个细胞(1ml中平均值为64,4个拷贝)。结论:接种疫苗不会对患者的免疫状态产生不利影响。未观察到严重的疫苗相关不良事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
А pilot project on vaccination against HPV was implemented among HIVinfected adolescents in Primorsky Krai
Purpose: to characterize the epidemiological features of HIV infection in children in the Primorsky Territory and to analyze the results of vaccination against human papillomavirus in adolescents with HIV infection.Materials and methods. They instilled against HPV 52 HIV-infected teenagers. Three times 51 patients, two times — 1.Results. Three-fold monitoring of the level of CD4-lymphocytes and viral load (VL) of HIV was carried out before vaccination, 3 and 6 months after. In all 52 individuals, 6 months before the forthcoming vaccination, the level of CD4-lymphocytes ranged from 350 to 1925 cells in 1 ml (the average value was 857,5), VL was determined from 0 to 300 copies in 1 ml (with an average value of 64,6). During vaccination, the level of CD4-lymphocytes tended to increase and ranged from 350 to 1952 cells in 1 ml (the average value was 884,1), while the VL indices even decreased from 0 to 274 (with an average value of 53,9 copies per 1 ml). 6 months after the completed vaccination, all indicators also practically did not change: the level of CD4-lymphocytes was from 353 to 1955 cells in 1 ml (the average value was 844,5), VL from 0 to 302 (with an average value of 64,4 copies in 1 ml).Conclusion. Vaccination did not adversely affect the immune status of patients. No serious vaccine-related adverse events were observed.
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来源期刊
HIV Infection and Immunosuppressive Disorders
HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases
CiteScore
0.70
自引率
0.00%
发文量
37
期刊介绍: In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.
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