高血压伴心房颤动或房扑患者血液中淋巴细胞和单核细胞亚群

Q4 Medicine
T. Talaieva, O. Sychov, O. Marchenko, I. Tretyak, N. Vasylynchuk, T. Getman, O. Romanova, O. Stasyshena, L. Vavilova
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引用次数: 0

摘要

心房颤动(AF)仍然是最常见的心律失常之一,仅次于室上性早搏,但其发生的普遍原因尚不清楚。心律失常发生的炎症理论引起了世界各国研究者的关注。本研究的目的是比较与动脉高压相关的阵发性和持续性心房颤动或心房扑动(AFL)患者血液中淋巴细胞和单核细胞的亚群。材料和方法。这项研究涉及103名继发于高血压的心房颤动和扑动患者。根据心律失常的形式,他们被分为三个主要组:第一组为阵发性心房颤动,第二组为持续性心房颤动,而第三组为持续型心房扑动。对照组包括有高血压但没有心律失常的患者和分别进入第IV组和第V组的健康人。外周血淋巴细胞和单核细胞亚群通过流式细胞术进行评估。结果和讨论。分析心房颤动和扑动患者(I、II和III组)外周血中的淋巴细胞亚群,发现具有细胞毒性活性的细胞(NK和NKT)的绝对计数和百分比值均显著高于健康个体。与对照组相比,心律失常患者的T调节细胞数量在统计学上显著减少(p≤0.05)。在与高血压相关的AF和AFL患者中,与没有这些心律失常的高血压患者或健康个体相比,经典和中间单核细胞亚群的数量增加。结论。与没有心律失常的患者或健康人相比,高血压引起的心房颤动和房扑患者的血液单核细胞、T细胞毒性细胞的促炎亚群含量增加,T调节细胞含量减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subpopulations of lymphocytes and monocytes in blood of patients with atrial fibrillation or atrial flutter associated with hypertension
Atrial fibrillation (AF) remains one of the most common arrhythmias, second only to supraventricular extrasystoles, but the universal cause of its occurrence is still unknown. The inflammatory theory of arrhythmogenesis attracts the attention of researchers around the world. The purpose of the study is to compare the subpopulations of lymphocytes and monocytes in blood of patients with paroxysmal and persistent forms of atrial fibrillation or atrial flutter (AFL) that associated with arterial hypertension. Materials and methods. The study involved 103 patients with atrial fibrillation and flutter that occurred secondary to hypertension. Depending on the form of arrhythmia, they were divided into three main groups: group I – with paroxysmal form of atrial fibrillation, group II – with a persistent form of atrial fibrillation, group III – with a persistent form of atrial flutter. The control groups included patients with hypertension, but without these arrhythmias and healthy individuals who entered groups IV and V, respectively. The lymphocytes and monocytes subpopulation was assessed by flow cytometry in peripheral blood. Results and discussion. Analyzing the lymphocyte subpopulations in peripheral blood of patients with atrial fibrillation and flutter (groups I, II and III), it was found that the number of cells with cytotoxic activity (NK and NKT) in both absolute count and percentage values was significantly higher than in healthy individuals. A statistically significant decrease of T-regulatory cells number was found in patients with arrhythmias compared to control groups (p ≤ 0.05). In patients with AF and AFL associated with hypertension, compared to patients with hypertension without these rhythm disturbances or healthy individuals, there is an increased number of classical and intermediate monocytes subpopulations. Conclusions. In patients with atrial fibrillation and atrial flutter that occurred as a result of hypertension, compared to patients without arrhythmias or healthy people, there is an increased content of pro-inflammatory subpopulations of blood monocytes, T-cytotoxic cells and a decrease in the content of T-regulatory cells.
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来源期刊
Cell and Organ Transplantology
Cell and Organ Transplantology Medicine-Transplantation
CiteScore
0.40
自引率
0.00%
发文量
8
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