抗纤维蛋白溶解在减少全髋关节置换术后失血中的作用及其对凝血特性的影响:一项前瞻性随机研究

A. Dahuja, Sabyasachi Bhowmik, Rashmeet Kaur, Radhe Shayam, Sandeep Jindal
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引用次数: 0

摘要

背景:研究表明氨甲环酸可减少全髋关节置换术患者的失血量和输血需求。然而,到目前为止,还没有足够大的研究来确定该药物在全髋关节置换术中是否安全有效。我们研究了静脉注射氨甲环酸与安慰剂相比,在全髋关节置换术中是否安全有效。材料与方法:对142例全髋关节置换术患者进行前瞻性、随机、双盲研究,随机分为氨甲环酸组和对照组。我们的方案包括在切口前15分钟在100 ml NS中给予一剂15mg /kg的TXA(在15分钟内输注),TXA组随后8小时。对照组术前滴注生理盐水100 ml,术后2 d滴注生理盐水100 ml,每次8小时。记录术后血液参数。结果:与对照组(804-878 ml)相比,接受TXA治疗的患者(352-412 ml)术后总排液量和输血需要量较低。我们在TXA组和对照组分别观察到3例和4例DVT。两组的凝血指标受影响最小。结论:我们的结论是氨甲环酸可以显著减少全髋关节置换术后的出血量和输血需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antifibrinolytic in reducing postoperative blood loss in total hip replacement and its effect on coagulation profile: A prospective randomized study
BACKGROUND: Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, till date, no study has been large enough to determine definitively whether the drug is safe and effective in total hip arthroplasty. We examined whether intravenous tranexamic acid, when compared with placebo, is safe and effective in total hip arthroplasty. MATERIALS AND METHODS: A prospective, randomized, double blinded study was conducted in a group of 142 patients undergoing total hip arthroplasty divided equally into tranexamic acid group and control group. Our protocol included administration of one dose of 15 mg/kg of TXA (given as infusion over 15 min ) in 100 ml NS just 15 min before incision and the subsequent 8 hourly in TXA group. In control group we have given 100 ml normal saline infusion just before operation and 100 ml NS infusion 8 hourly for 2 days postoperatively. Postoperative blood parameters were recorded. RESULTS: The total postoperative drain output and transfusion requirement was found to be lower in patients who received TXA (352-412 ml) as compared to control group (804-878 ml). We have observed 3 and 4 cases of DVT in TXA and control group respectively. Coagulation profile is least affected in both the groups. CONCLUSION: We conclude that tranexamic acid significantly reduces postoperative blood loss and transfusion requirements during total hip arthroplasty.
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