肾脏交换计划中已故供者启动链的长期模拟分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-04 eCollection Date: 2024-01-01 DOI:10.1080/20476965.2023.2197023

Utkarsh Verma, Nayaran Rangaraj, Viswanath Billa, Deepa Usulumarty

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引用次数: 0

摘要

肾脏交换项目已经发展起来，为有不相容供体的受者寻找相容的肾脏。另一方面，没有活体捐赠者的患者依靠已故捐赠者(DD)的捐赠来获得肾脏移植。目前，在印度，已故捐赠者直接将肾脏捐赠给等待捐赠的已故捐赠者。在一些文章中提出了从已故捐赠者的肾脏开始启动交换链的想法(最近在意大利实施)，但没有给出这种合并的数学公式。我们引入了一个整数规划公式，该公式可以创建已故捐赠者发起的链，同时考虑配对交换注册和已故捐赠者分配。配对交换登记和已故捐赠者等候名单登记数据之间可能存在重叠，因为接受者可以独立地为这两个登记进行登记。本文也对此进行了论述。我们进行了长期的模拟研究，以分析这些DD启动链随时间的增益。这表明，即使只有少量的已故捐献者，这些器官链也能显著增加潜在的移植数量。此外，合并注册表中的等待时间和退出率也大大降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Long term simulation analysis of deceased donor initiated chains in kidney exchange programs.

Kidney exchange programs (KEPs) aim to find compatible kidneys for recipients with incompatible donors. Patients without a living donor depend upon deceased donor (DD) donations to get a kidney transplant. In India, a ©DD donates kidneys directly to a©DD wait-list. The idea of initiating an exchange chain starting from a ©DD kidney is proposed in a few articles (and executed in Italy in 2018), but no mathematical formulation has been given for this merger. We have introduced an integer programming formulation that creates ©DD-initiated chains, considering both paired exchange registry and ©DD allocations simultaneously and addressing the overlap issue between the exchange registry and ©DD wait-list as recipients can register for both registries independently. A long-term simulation study is done to ©analyse the gain of these DD-initiated chains over time. It suggests that even with small numbers of ©DDs, these chains can significantly increase potential transplants.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.