Cannabis sativa L.: A Comprehensive review on legislation, decriminalization, phytochemistry, antimicrobial activity, and safety

Throughout history, medicinal and aromatic plants have been used extensively to cure a variety of ailments. This article provides a comprehensive overview of Cannabis sativa , speci fi cally focusing on its legislative status, decrimi-nalization, phytochemistry, antimicrobial activity, and safety. The study begins by brie fl y outlining the plant ' s history, including its cultivation, harvesting, and storage methods. The review analyzes extensively the antimicrobial properties of Cannabis sativa and its derivatives, speci fi cally examining their reported antiviral, antibacterial, antifungal, and antiparasitic capabilities, which have been documented in databases such as Scopus, ScienceDirect, PubMed, and Web of Science. The paper also discusses trends in studies about the plant object of the study, the different bioactive compounds that were identi fi ed in the plant (phenolic acids, fl avonoids, alkaloids, cannabinoids, and terpenes), and safe consumption in several cannabis-based products including candies, desserts, wine and as food fl avoring. Furthermore, this study has reported information about the legalization and decriminalization of cannabis use across the globe with a speci fi c focus on Morocco because it has the largest cultivated area of C. sativa plant. However, some substances with potential antimicrobial properties were not investigated in this review due to the lack of data on their activity. The authors hope that their efforts will inspire future studies on the therapeutic uses of Cannabis sativa and its derivatives, ultimately leading to improved health outcomes.