{"title":"非经典HLA-E、-F、-G分子在肿瘤微环境中的表达","authors":"A. Ormandjieva","doi":"10.2478/fco-2022-0008","DOIUrl":null,"url":null,"abstract":"Abstract The human leukocyte antigen complex (HLA) is mainly known for its highly polymorphic classical molecules (class Ia and class II), which play a role in tumour immune modulation. The focus of this review, however, is on non-classical, significantly less polymorphic HLA-E, -F, and -G molecules (HLA-Ib), which are expressed by both immune and malignant cells in the tumour microenvironment. Recent findings indicate that the presence of HLA-G and -E in malignant tumours is associated with lowered overall survival of patients, whereas HLA-F is the least investigated and information about its role is more limited.","PeriodicalId":38592,"journal":{"name":"Forum of Clinical Oncology","volume":"0 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment\",\"authors\":\"A. Ormandjieva\",\"doi\":\"10.2478/fco-2022-0008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract The human leukocyte antigen complex (HLA) is mainly known for its highly polymorphic classical molecules (class Ia and class II), which play a role in tumour immune modulation. The focus of this review, however, is on non-classical, significantly less polymorphic HLA-E, -F, and -G molecules (HLA-Ib), which are expressed by both immune and malignant cells in the tumour microenvironment. Recent findings indicate that the presence of HLA-G and -E in malignant tumours is associated with lowered overall survival of patients, whereas HLA-F is the least investigated and information about its role is more limited.\",\"PeriodicalId\":38592,\"journal\":{\"name\":\"Forum of Clinical Oncology\",\"volume\":\"0 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Forum of Clinical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2478/fco-2022-0008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forum of Clinical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2478/fco-2022-0008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment
Abstract The human leukocyte antigen complex (HLA) is mainly known for its highly polymorphic classical molecules (class Ia and class II), which play a role in tumour immune modulation. The focus of this review, however, is on non-classical, significantly less polymorphic HLA-E, -F, and -G molecules (HLA-Ib), which are expressed by both immune and malignant cells in the tumour microenvironment. Recent findings indicate that the presence of HLA-G and -E in malignant tumours is associated with lowered overall survival of patients, whereas HLA-F is the least investigated and information about its role is more limited.