脑特异性血管生成抑制剂1在突触和认知障碍中的作用

中华行为医学与脑科学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.11.017

Z. Mou, Dan Wang

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引用次数: 0

摘要

粘附G蛋白偶联受体（aGPCR）在认知障碍相关疾病中发挥着重要作用。作为aGPCR的重要成员，脑特异性血管生成抑制剂1（BAI1）在抗血管生成、抗肿瘤和参与免疫吞噬等方面具有显著影响。最近的研究发现BAI1对突触发生和突触可塑性有很大影响，但很少有研究涉及BAI1在神经系统中的作用。如今，人口老龄化加剧了认知障碍的发生。阿尔茨海默病和血管认知障碍的发病机制仍然难以捉摸，早期识别认知障碍面临挑战。在轻度认知障碍阶段，突触损伤是明显的。BAI1可以调节突触后膜的功能、突触发生、突触信号传递和树突棘的形态发育。因此，它可能成为认知障碍的预警指标和干预目标。关键词：脑特异性血管生成抑制剂1；认知障碍；粘附G蛋白偶联受体；突触发生；轻度认知障碍

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Role of brain-specific angiogenesis inhibitor 1 in synapse and cognitive impairment

Adhesion G protein-coupled receptors(aGPCRs) play a significant role in cognitive impairment related diseases. As an important member of aGPCRs, brain-specific angiogenesis inhibitor 1(BAI1) has a prominent impact on anti-angiogenesis, anti-tumor and participating in immune phagocytosis. Recent research found out that BAI1 exerts a great influence on synaptogenesis and synaptic plasticity, but few studying concerning BAI1 in nervous system. Nowadays, the aging of population aggravates the occurrence of cognitive impairment. The pathogenesis of Alzheimer's disease and vascular cognitive impairment remains elusive, and identification of cognitive impairment at an early stage faces challenges. In the stage of mild cognitive impairment, synaptic damage is evident. BAI1 can regulate the function of postsynaptic membrane, synaptogenesis, synaptic signal transmission and the morphological development of dendritic spines. Therefore, it may potentially act as an early-warning index and intervention target for cognitive impairment. Key words: Brain-specific angiogenesis inhibitor 1; Cognitive impairment; Adhesion G protein-coupled receptors; Synaptogenesis; Mild cognitive impairment

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来源期刊

中华行为医学与脑科学杂志

自引率

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发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.