干细胞移植治疗脊髓损伤的机制及临床应用相关问题

中华创伤杂志 Pub Date : 2019-07-15 DOI:10.3760/CMA.J.ISSN.1001-8050.2019.07.003

B. He

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引用次数: 0

摘要

脊髓损伤常伴有脊髓损伤区以下感觉、运动和自主神经功能的丧失。它的预后很差，经常导致终身残疾，甚至死亡。到目前为止，还没有有效的治疗方法来彻底修复脊髓损伤。干细胞是一类具有分化为神经元潜力的细胞，可以通过修复或替换受损的神经元、分泌神经营养因子、抑制局部炎症反应发挥治疗作用。各种干细胞通常用于移植，但它们有各自的优点和缺点。移植的主要方法有蛛网膜下腔注射、静脉注射和病灶内注射。本文综述了干细胞的种类、干细胞移植的方法、移植时间、治疗效果及可能的机制，为干细胞治疗脊髓损伤的基础和临床研究提供参考。关键词：脊髓损伤；干细胞；细胞移植

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Related issues on mechanism and clinical application of stem cell transplantation for spinal cord injury

Spinal cord injury is often accompanied by the loss of sensory, motor and autonomic nerve function below the spinal cord injury area. It has poor prognosis and often leads to life-long disability, even death. To date, there is no effective treatment for radical functional repair of spinal cord injury. Stem cells are a class of cells with the potential to differentiate into neurons, which can play a therapeutic role through remedying or replacing the damaged neurons, secreting neurotrophic factors, inhibiting local inflammatory response. A variety of stem cells are commonly used in transplantation, but they have their own advantages and disadvantages. The main methods of transplantation include subarachnoid injection, intravenous injection and intralesional injection. This article reviews the types of stem cells, the methods of stem cell transplantation, the time of transplantation, the therapeutic effect and the possible mechanism so as to provide reference for the basic and clinical research of stem cell therapy for spinal cord injury. Key words: Spinal cord injuries; Stem cells; Cell transplantation

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来源期刊

中华创伤杂志

自引率

0.00%

发文量

11327

期刊介绍： Chinese Journal of Trauma (International Standard Serial Publication Number: ISSN 1001-8050, Domestic Uniform Serial Publication Number: CN 50-1098/R) was founded in September 1985, which is the only high-level medical professional academic journal that can comprehensively and systematically reflect the achievements and development trends of China's traumatology medicine, and has a wide academic influence in China's traumatology medicine community. It has a wide range of academic influence in China's trauma medicine. Chinese Journal of Trauma is a source journal of China Science and Technology Paper Statistics, a source journal of China Science Citation Database (CSCD), a core journal of China Comprehensive Medicine and Health Care, a source journal of China Academic Journals Comprehensive Evaluation Database (CAJCED), a full-text journal of China Journal Full-text Database (CJFD), a core academic journal of China Center for Scientific Evaluation (RCCSE), a core academic journal of China Traumatology and Traumatology Center (CTC), a core academic journal of China Traumatology Center (RCCSE). RCCSE) core academic journals; Chinese Biomedical Journal Database (CMCC), Chinese Biomedical Journal Citation Database (CBJCED), China Journal Network (CJN), China Academic Journals (CD-ROM), Chinese Academic Journals Abstracts (Chinese Edition), Chemical Abstracts of the United States (CA), Index Copernicus of Poland (IC), and Japan Institute of Science and Technology Database (JICST), World Health Organization Western Pacific Region Medical Search (WPRIM) and Russian Journal of Abstracts (ΡЖ) included journals.