致激效应剂量-反应污染物引起的动物致激效应

IF 6.1 Q1 TOXICOLOGY

Current Opinion in Toxicology Pub Date : 2022-06-01 DOI:10.1016/j.cotox.2022.02.009

Rachel R. Rix , Raul Narciso C. Guedes , G. Christopher Cutler

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引用次数: 21

摘要

激效是一种毒理学现象，即暴露于低剂量的压力下导致生物刺激。致热剂量反应现在被认为是毒理学中主要的反应，发生在多种生物体暴露于多种形式的应激后。在这里，我们简要回顾了最近的研究，这些研究表明动物在暴露于频繁发生的环境相关污染物/污染物(包括金属、工业化学品、农药、药品和塑料)后会产生激效。我们还展示了激效的潜在机制的证据。最后，我们强调在研究环境污染的后果时考虑低剂量效应和激效的重要性。

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Hormesis dose–response contaminant-induced hormesis in animals

Hormesis is a toxicological phenomenon whereby exposures to low doses of stress result in biological stimulation. The hormetic dose response is now recognized as a dominant response in toxicology occurring in a wide variety of organisms following exposure to numerous forms of stress. Here we briefly review recent research showing occurrences of hormesis in animals following exposure to frequently occurring and environmentally relevant contaminants/pollutants, including metals, industrial chemicals, pesticides, pharmaceuticals, and plastics. We also show evidence for underlying mechanisms for hormesis. We conclude by highlighting the importance of considering low-dose effects and hormesis when studying the consequences of environmental contamination/pollution.

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来源期刊

Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

10.40

自引率

0.00%

发文量

期刊介绍： The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.