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Ugi反应合成新型二萜肽及其抗癌活性

IF 0.6 Q4 CHEMISTRY, ORGANIC
Molbank Pub Date : 2023-08-01 DOI:10.3390/m1707
A.A. Smirnova, L. Zakirova, I. Smirnova, E. Tretyakova
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引用次数: 0

摘要

采用Ugi四组分反应在常温下合成了新型二萜肽衍生物。该方案采用甲醛、苯胺、相应的二萜酸和2-异氰乙酸乙酯之间的反应。体外研究了化合物的抗癌特性。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro.
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来源期刊
Molbank
Molbank Chemistry-Physical and Theoretical Chemistry
CiteScore
0.70
自引率
33.30%
发文量
174
审稿时长
11 weeks
期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)
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