代谢工程是产生高效生物活性物质生产者的一种很有前途的方法

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
A. Blokhina, KA Palkina, E. Shakhova, AK Malyshevskaia, Z. Osipova, N. Myshkina
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引用次数: 0

摘要

药物在延长生命和提高生活质量方面发挥着无可争议的作用。为了获得药用化合物,研究人员传统上依赖于天然来源和化学合成,然而,目前正在开发的生物技术方法允许将编码新代谢途径的基因组引入异源宿主的基因组中,并调节宿主内在代谢途径的活性。这种方法使在异源宿主中复制生物活性物质的生物合成成为可能,该方法结合了传统方法的优点,并围绕着这些方法的结合而工作。在我们看来,利用代谢工程获得药用化合物对其生产越来越重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic engineering is a promising way to generate highly effective producers of bioactive substances
Medicines play an indisputable role in life extension and improvement of the quality of life. To obtain medicinal compounds, researchers traditionally rely on natural sources and chemical synthesis, however, currently developing biotechnological methods allow one to introduce the group of genes encoding new metabolic pathways into the genomes of heterologous hosts and regulate activity of the hosts' intrinsic metabolic pathways. Such an approach makes it possible to reproduce biosynthesis of bioactive substances in heterologous hosts, the approach combines the benefits of conventional methods and works around the shorcomings of those. In our view, the use of metabolic engineering to obtain medicinal compounds is becoming increasingly important for their production.
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来源期刊
Bulletin of Russian State Medical University
Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
59
期刊介绍: Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.
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