异戊基(E) 3 - (3 4-Dimethoxyphenyl)丙烯酸酯

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-08-02 DOI:10.3390/m1708

Egar Pamela, Lukman Atmaja, Mardi Santoso

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引用次数: 0

摘要

以2-甲基-6-硝基苯甲酸酐(MNBA)/4-二甲氨基吡啶(DMAP)为催化剂，在二氯甲烷中室温反应190 min，收率为95%，得到了丙烯酸异戊基(E)-3-(3,4-二甲氧基苯基)丙烯酸酯(1)。采用核磁共振、红外光谱和高分辨率质谱等手段对丙烯酸异戊基(E)-3-(3,4-二甲氧基苯基)酯(1)的结构进行了表征。体外防晒系数评价值为37.10±0.03，表明异戊基(E)-3-(3,4-二甲氧基苯基)丙烯酸酯(1)是一种具有较高防晒效果的防晒剂。

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Isoamyl (E)-3-(3,4-Dimethoxyphenyl)acrylate

Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was elucidated using NMR, FTIR, and high-resolution mass spectrometry. In vitro sun protection factor evaluation exhibited a value of 37.10 ± 0.03 which indicates that isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) is a sunscreen agent with high protection.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)