{"title":"巴豆刺叶属新盐烷和氯烷二萜","authors":"Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin","doi":"10.1007/s13659-023-00386-z","DOIUrl":null,"url":null,"abstract":"<div><p>Three new halimane furanoditerpenoids (<b>1</b>–<b>3</b>) and three new clerodane furanoditerpenoids (<b>4</b>–<b>6</b>), along with seven known terpenoids including four pimarane diterpenoids (<b>7</b>–<b>10</b>) and three norisoprenoids (<b>11</b>–<b>13</b>) were isolated from the 95% EtOH extracts of the plants of <i>Croton cnidophyllus</i>. The 2D structures including absolute configuration of new furanoditerpenoids (<b>1</b>–<b>6</b>) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (<b>8</b> and <b>9</b>) possessed certain inhibitory effects against NO production stimulated by LPS, with IC<sub>50</sub> values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.</p><h3>Graphical Abstract</h3>\n <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\n </div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"13 1","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-023-00386-z.pdf","citationCount":"0","resultStr":"{\"title\":\"New halimane and clerodane diterpenoids from Croton cnidophyllus\",\"authors\":\"Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan, Gui-Hua Tang, Sheng Yin\",\"doi\":\"10.1007/s13659-023-00386-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Three new halimane furanoditerpenoids (<b>1</b>–<b>3</b>) and three new clerodane furanoditerpenoids (<b>4</b>–<b>6</b>), along with seven known terpenoids including four pimarane diterpenoids (<b>7</b>–<b>10</b>) and three norisoprenoids (<b>11</b>–<b>13</b>) were isolated from the 95% EtOH extracts of the plants of <i>Croton cnidophyllus</i>. The 2D structures including absolute configuration of new furanoditerpenoids (<b>1</b>–<b>6</b>) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (<b>8</b> and <b>9</b>) possessed certain inhibitory effects against NO production stimulated by LPS, with IC<sub>50</sub> values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.</p><h3>Graphical Abstract</h3>\\n <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\\n </div>\",\"PeriodicalId\":718,\"journal\":{\"name\":\"Natural Products and Bioprospecting\",\"volume\":\"13 1\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2023-07-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s13659-023-00386-z.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Products and Bioprospecting\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13659-023-00386-z\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-023-00386-z","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
New halimane and clerodane diterpenoids from Croton cnidophyllus
Three new halimane furanoditerpenoids (1–3) and three new clerodane furanoditerpenoids (4–6), along with seven known terpenoids including four pimarane diterpenoids (7–10) and three norisoprenoids (11–13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1–6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC50 values of 19.00 ± 1.76 and 21.61 ± 1.11 μM, respectively.
期刊介绍:
Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects:
Natural products: isolation and structure elucidation
Natural products: synthesis
Biological evaluation of biologically active natural products
Bioorganic and medicinal chemistry
Biosynthesis and microbiological transformation
Fermentation and plant tissue cultures
Bioprospecting of natural products from natural resources
All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.