四氢异喹啉类生物碱、喹诺卡因和柠檬霉素的全合成研究进展

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2023-08-01 DOI:10.2174/1570193x20666230801101427

Yang Yang, Junan Guo, Lanhua Shen, Jingyi Li, Fuan Li, Sifan Wang

{"title":"四氢异喹啉类生物碱、喹诺卡因和柠檬霉素的全合成研究进展","authors":"Yang Yang, Junan Guo, Lanhua Shen, Jingyi Li, Fuan Li, Sifan Wang","doi":"10.2174/1570193x20666230801101427","DOIUrl":null,"url":null,"abstract":"\n\nTetrahydroisoquinoline natural products are a kind of alkaloids containing various pharmacological activities. These structurally diverse alkaloids mainly consist of two subclasses, monotetrahydroisoquinolines(MTHI) and bistetrahydroisoquinolines(BTHI). Since its family member, Ecteinascidin-743 (INN: Trabectedin, trade name: Yondelis® ), has been approved by European Union in 2007 and the FDA in 2015 for the treatment of advanced soft tissue tumors, the research on this kind of natural product is full of new vitality. Quinocarcin and lemonomycin share a common diazabicyclo[3.2.1]octane framework that belongs to the subclass of MTHI, and their excellent antitumor activity and challenging architecture have made them an ideal target for total synthesis. In this short review, the progress in the total synthesis of quinocarcin and lemonomycin is summarized.\n","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent Advances in Total Synthesis of Tetrahydroisoquinoline Alkaloids Quinocarcin and Lemonomycin\",\"authors\":\"Yang Yang, Junan Guo, Lanhua Shen, Jingyi Li, Fuan Li, Sifan Wang\",\"doi\":\"10.2174/1570193x20666230801101427\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nTetrahydroisoquinoline natural products are a kind of alkaloids containing various pharmacological activities. These structurally diverse alkaloids mainly consist of two subclasses, monotetrahydroisoquinolines(MTHI) and bistetrahydroisoquinolines(BTHI). Since its family member, Ecteinascidin-743 (INN: Trabectedin, trade name: Yondelis® ), has been approved by European Union in 2007 and the FDA in 2015 for the treatment of advanced soft tissue tumors, the research on this kind of natural product is full of new vitality. Quinocarcin and lemonomycin share a common diazabicyclo[3.2.1]octane framework that belongs to the subclass of MTHI, and their excellent antitumor activity and challenging architecture have made them an ideal target for total synthesis. In this short review, the progress in the total synthesis of quinocarcin and lemonomycin is summarized.\\n\",\"PeriodicalId\":18632,\"journal\":{\"name\":\"Mini-reviews in Organic Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mini-reviews in Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/1570193x20666230801101427\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini-reviews in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/1570193x20666230801101427","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

四氢异喹啉天然产物是一类具有多种药理活性的生物碱。这些生物碱结构多样，主要包括单四氢异喹啉(MTHI)和双四氢异喹啉(BTHI)两个亚类。自家族成员Ecteinascidin-743 (INN: Trabectedin，商品名:Yondelis®)于2007年获欧盟批准，2015年获FDA批准用于晚期软组织肿瘤治疗以来，对这类天然产物的研究充满了新的活力。喹诺卡素和柠檬霉素具有共同的重氮比环[3.2.1]辛烷值框架，属于MTHI亚类，其优异的抗肿瘤活性和具有挑战性的结构使其成为全合成的理想靶点。本文综述了喹诺卡素和柠檬霉素全合成的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Recent Advances in Total Synthesis of Tetrahydroisoquinoline Alkaloids Quinocarcin and Lemonomycin

Tetrahydroisoquinoline natural products are a kind of alkaloids containing various pharmacological activities. These structurally diverse alkaloids mainly consist of two subclasses, monotetrahydroisoquinolines(MTHI) and bistetrahydroisoquinolines(BTHI). Since its family member, Ecteinascidin-743 (INN: Trabectedin, trade name: Yondelis® ), has been approved by European Union in 2007 and the FDA in 2015 for the treatment of advanced soft tissue tumors, the research on this kind of natural product is full of new vitality. Quinocarcin and lemonomycin share a common diazabicyclo[3.2.1]octane framework that belongs to the subclass of MTHI, and their excellent antitumor activity and challenging architecture have made them an ideal target for total synthesis. In this short review, the progress in the total synthesis of quinocarcin and lemonomycin is summarized.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry