洋紫荆中富含皂苷的部分。改善大鼠肾结石形成

IF 0.1 0 VETERINARY SCIENCES
A. Patel, Hital Shah, T. Gandhi
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引用次数: 0

摘要

本研究旨在了解紫荆富含皂苷的提取物的作用。(SREBV)。SREBV的定性和定量分析显示存在bbbbb-谷甾醇、豆甾醇和羽扇豆醇。对雄性Wistar大鼠给予乙二醇(0.75%v/v,蒸馏水)28天,成功诱导尿石症,伴有高草酸尿、高钙尿以及肾脏尿酸和无机磷酸盐排泄增加。补充SREBV通过利尿显著降低了这些促结石因子的水平,并增加了镁等结石抑制剂的水平。SREBV给药大鼠的肌酸酐、尿酸和血尿素氮显著降低。此外,SREBV治疗的大鼠肾组织中草酸钙晶体沉积减少,肾保护作用明显。SREBV的抗锂活性也得到了其在体外DPPH测定中所描述的自由基清除活性以及在体内减轻脂质过氧化和提高抗氧化酶水平的支持。这项研究表明,补充SREBV可以保护EG诱导的尿路结石,因为它可以缩短尿路结石的生长。这种作用的机制可能是由于其抗氧化、利尿、保护肾脏和抑制结石形成的成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Saponin rich fraction of Bauhinia variegata Linn. ameliorates kidney stone formation in rats
: The present study was planned to know the effect of saponin-rich extract of Bauhinia variegata Linn. (SREBV) in an ethylene glycol induced urolithiasis model. The qualitative and quantitative analysis of SREBV revealed presence of bbbbb -sitosterol, stigmasterol and lupeol. Administration of ethylene glycol (0.75% v/v in distilled water) to male Wistar rats for 28 days successfully induced urolithiasis with hyperoxaluria, hypercalciuria as well as an increased renal excretion of uric acid and inorganic phosphate. Supplementation with SREBV significantly decreased these levels of stone promotor via diuresis and increased levels of stone inhibitor like magnesium. There was a significant reduction in creatinine, uric acid, and blood urea nitrogen in rats administered with SREBV. Moreover, reno-protective effect is evident by decreased deposits of calcium-oxalate crystals in the kidney tissue of SREBV treated rats. The antilithiatic activity of SREBV is also supported by its radical scavenging activity portrayed in DPPH assay in-vitro as well as alleviation in lipid peroxidation and improvement in antioxidant enzyme levels in-vivo . With this study, it was clinched that the SREBV supplementation safeguarded EG-induced urolithiasis as it abbreviated the growth of urinary stones. The mechanisms attributing to this effect might be due to its antioxidant, diuretic, nephroprotective and curbing in stone-forming constituents.
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来源期刊
CiteScore
1.30
自引率
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16
审稿时长
20 weeks
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