用斑马鱼模型评价印度药物制剂Nilavembu Kudineer和Mathulai Manapagu致畸性

Q2 Social Sciences

Studies on Ethno-Medicine Pub Date : 2019-07-08 DOI:10.31901/24566772.2019/13.04.592

M. Ramasamy

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引用次数: 0

摘要

致畸剂是一种能够破坏DNA并干扰胚胎发育的药物或其他物质，它可能导致出生缺陷或发育畸形。本研究旨在评价印度药物Nilavenbu Kudineer和Madulai Manapagu。在Siddha系统中，Nilavenbu Kudineer用于治疗登革热，而Madulai Manapagu用于改善女性血红蛋白含量和激素失衡的管理。结果表明，马杜拉伊·马纳帕古的总死亡率、孵化率和畸形率低于尼拉文布·库迪内尔。Nilavenbu Kudineer的致畸指数高于1（1.33），而LC50 EC50值分别为80μg/ml和60μg/ml。因此，Nilavenbu Kudineer与Madulai Manapagu相比被认为是致畸的。

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Evaluation of Teratogenicity Indian Medicine Formulations Nilavembu Kudineer and Mathulai Manapagu using Zebrafish Model

A teratogen is a drug or other substance capable of damaging the DNA and interfering with the development of an embryo and it may lead to birth defects or developmental malformations. The present study is carried out to evaluate the Indian Medicines Nilavembu Kudineer and Madulai Manapagu. In Siddha system, Nilavembu Kudineer is given to treat Dengue fever whereas Madulai Manapagu is to improve the hemoglobin content and the management of hormonal imbalance in women. The results exemplified the overall percentage mortality, hatchability, and deformities were observed as low in Madulai Manapagu than Nilavembu Kudineer. The teratogenic index of Nilavembu Kudineer is higher than 1 (1.33), whereas LC50 EC50 values were observed as 80 μg/ ml and 60 μg/ml respectively. Hence, Nilavembu Kudineer is considered as teratogenic when compared to Madulai Manapagu.

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来源期刊

Studies on Ethno-Medicine Social Sciences-Cultural Studies

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Studies on Ethno-Medicine is a peer reviewed, internationally circulated journal. It publishes reports of original research, theoretical articles, timely reviews, brief communications, book reviews and other publications in the interdisciplinary field of ethno-medicine. The journal serves as a forum for physical, social and life scientists as well as for health professionals. The transdisciplinary areas covered by this journal include, but are not limited to, Physical Sciences, Anthropology, Sociology, Geography, Life Sciences, Environmental Sciences, Botany, Agriculture, Home Science, Zoology, Genetics, Biology, Medical Sciences, Public Health, Demography and Epidemiology. The journal publishes basic, applied and methodologically oriented research from all such areas. The journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscript of unusual interest. Further, the manuscripts are categorised under three types, namely - Regular articles, Short Communications and Reviews. The researchers are invited to submit original papers in English (papers published elsewhere or under consideration elsewhere shall not be considered).