Wolfram病的躁狂：从床边到长椅

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2017-02-01 DOI:10.9758/cpn.2017.15.1.70

Seshadri Sekhar Chatterjee, S. Mitra, S. K. Pal

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引用次数: 5

摘要

Wolfram综合征在临床精神病学中是一个相对未被探索的实体。从历史上看，特定WFS1基因的发现在精神疾病的特定遗传原因方面引起了巨大的轰动。虽然最初的热情现在已经消退，但Wolfram综合征与精神分裂症、精神病和自杀行为等精神疾病的联系对于理解这些疾病的生物学基础仍然很重要。我们报告一例Wolfram综合征表现为多次躁狂发作，讨论可能的遗传基础的情感症状，然后讨论有关管理的某些问题。

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Mania in Wolfram’s Disease: From Bedside to Bench

Wolfram syndrome is a relatively unexplored entity in clinical psychiatry. Historically, the discovery of a specific WFS1 gene had generated huge fanfare regarding specific genetic causations of psychiatric disorders. While the initial enthusiasm has faded now, association of Wolfram syndrome with psychiatric illnesses like schizophrenia, psychosis and suicidal behavior still remain important for understanding biological underpinnings of such disorders. We report a case of Wolfram syndrome presenting with multiple manic episodes, discuss possible genetic underpinnings for the affective symptoms and then discuss certain issues regarding management.

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.