食蟹狐狸结肠乳头状腺癌的解剖病理和免疫组织化学特征

Q4 Veterinary

Brazilian Journal of Veterinary Pathology Pub Date : 2022-03-31 DOI:10.24070/bjvp.1983-0246.v15i1p38-43

R. M. Pereira, J. L. de Araujo, Márcio A. Silva, G. B. S. Filho, H. A. Bom, L. D. Aires, F. A. Souza, F. Mendonça

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引用次数: 0

摘要

捕获的17岁雄性食蟹狐(Cerdocyon thous)出现缺氧和便秘两周的临床症状死亡。尸检发现，一个大而坚固的肿块扩张了大肠壁，完全阻塞了结肠腔。组织病理学显示为非包膜性界限不清的腺癌，由立方到假层状柱状上皮组成，形成大小不一的乳头状突起。肿瘤细胞细胞质中CK7和PAN-CK阳性，VIM和CK20阴性。免疫组织化学显示其免疫表型与人类和家养狗的肠腺癌不同。本文为首例食蟹狐结肠乳头状腺癌病例报告。

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Colonic papillary adenocarcinoma in a crab-eating fox (Cerdocyon thous): Anatomopathological and immunohistochemical features

A captive 17-year-old male crab-eating fox (Cerdocyon thous) presenting clinical signs of hyporexia and constipation for two weeks was found dead. On autopsy, a large and firm mass expanding the large intestine wall and totally obstructing the colon lumen was identified. Histopathology revealed a non-encapsulated poorly demarcated adenocarcinoma composed of cuboidal to pseudostratified columnar epithelium forming papillary projections of variable sizes. The cytoplasm of the neoplastic cells was immunopositive for CK7 and PAN-CK, but negative for VIM and CK20. Immunohistochemistry revealed an immunophenotype different from the enteric adenocarcinomas reported in humans and domestic dogs. This is the first case report of colonic papillary adenocarcinoma in a crab-eating fox.

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来源期刊

Brazilian Journal of Veterinary Pathology Veterinary-Veterinary (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Brazilian Journal of Veterinary Pathology is the official electronic periodical of the Brazilian Association of Veterinary Pathology. The purpose of the BJVP is to publish original full papers, short communications, case reports, letters, reviews (by invited experts) and abstracts of scientific meetings. The preferable subjects is natural and experimental pathology. All the articles are submitted to scientific reviewers.