氯氮平治疗亨廷顿舞蹈症中的精神病和舞蹈病系统叙述综述

IF 1.3 Q4 NEUROSCIENCES

Progress in Neurology and Psychiatry Pub Date : 2022-04-01 DOI:10.1002/pnp.750

Bethany Wildridge, S. Rozewicz, A. Mohamed, J. James, Gerard Connolly

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引用次数: 2

摘要

亨廷顿舞蹈症的退行性本质极大地降低了患者的生活质量，同时也限制了预期寿命。除其他原因外，精神病和舞蹈病仍然是患者难以控制的疾病表现。氯氮平是一种非典型的抗精神病药物，具有多神经受体亲和力，具有广泛的作用。氯氮平已被证明对亨廷顿舞蹈症患者的舞蹈和精神病有良好的治疗作用。在这里，作者提出了进一步研究的理由。

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Use of clozapine for psychosis and chorea in Huntington's disease systematic narrative review

The degenerative nature of Huntington's disease drastically reduces quality of life for sufferers while limiting life expectancy itself. Among other sequalae, psychosis and chorea remain persistently difficult disease manifestations to manage for patients. Clozapine is an atypical antipsychotic medication with a multineuroreceptor affinity, which gives it a broad range of action. Clozapine has been documented to have good remedial actions on chorea and psychosis in patients with Huntington's disease. Here the authors make the case for further research.

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来源期刊

Progress in Neurology and Psychiatry NEUROSCIENCES-

CiteScore

1.70

自引率

8.30%

发文量

期刊介绍： Progress in Neurology and Psychiatry is published nine times a year, and is a journal for specialists in secondary care, GPs with an interest in neurology and psychiatry, community psychiatric nurses and other specialist healthcare professionals. Articles cover management, news updates and opinion in all areas of neurology and psychiatry.