恢复期血浆治疗:SARS-CoV-2爆发的一个有希望的解决方案

Q3 Biochemistry, Genetics and Molecular Biology
A. Singh, A. Chaterjee, S. Sirohi, Nikhil Sharma, A. Kathuria
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引用次数: 1

摘要

自2019年11月爆发(新冠肺炎)以来,严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)已在全球范围内造成超过1800万例确诊病例和70万人死亡。它被认为是这一类别下最具致病性的感染。迄今为止,没有任何研究人员声称有任何治疗或预防措施可以治愈严重急性呼吸系统综合征冠状病毒2型感染的患者。迫切需要任何替代和有效的新冠肺炎疾病管理方法。然而,随着患者生存率的显著提高,恢复期血浆治疗(CPT)引起了研究人员的关注。有趣的是,有许多例子表明,CPT已证明其在包括新冠肺炎在内的各种疾病的暴露后预防和/或治疗中的潜力。本文综述了CPT的基本要素、其过去的临床证据以及CPT在新冠肺炎期间管理SARS-CoV-2感染中的应用。截至2020年5月31日,我们使用了PubMed、EMBASE和Medline数据库中已发表的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Convalescent plasma therapy: A promising solution for SARS-CoV-2 outbreak
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has caused more than 18 million confirmed cases and 700000 deaths worldwide after the outbreak in November 2019 (COVID-19). It has been considered as most pathogenic infection under this category. Till date none of the therapeutics or prophylaxis measures have been claimed by any researcher which could cure the patient suffering from the SARS-CoV-2 infection. There is an urgent need for any alternative and effective way of disease management for COVID-19. However, convalescent plasma therapy (CPT) has gain attention of researchers with significant improvement of patient survival rate. Interestingly, there are numerous examples where CPT has proven its potential upon post-exposure prophylaxis and/or treatment in various diseases including COVID-19. This review summarizes the essential elements related to CPT, its past clinical evidences and application of CPT for the management of SARS-CoV-2 infection during COVID-19. We used the published literatures from PubMed, EMBASE and Medline databases until 31st May 2020.
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来源期刊
Journal of Cellular Biotechnology
Journal of Cellular Biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
0.70
自引率
0.00%
发文量
13
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