新冠肺炎临床试验中潜在的候选药物:最新综述

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY
O. I. A. Cáceres, Timóteo Fernanda, Kristiane Fanti Del Pino Santos, Rafael Rodrigo Piva Vasconcelos, M. Martines, Juliana Jorge, H. Rashid
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引用次数: 0

摘要

冠状病毒(严重急性呼吸系统综合征冠状病毒2型)于2019年12月在中国武汉出现,截至2020年4月底,它已传播到全球200多个国家。截至2020年12月,美国、巴西、西班牙、意大利、法国、德国、英国、土耳其、伊朗和俄罗斯是受影响最严重的国家。目前,大多数研究人员都在持续努力开发抗击新冠肺炎的疫苗或新药。有30多种候选药物,包括西药、天然产物和中药,已显示出对这种高度传染性病毒的一些疗效。这篇综述包括最近针对新冠肺炎测试的一些关键药物的潜在疗效。随着新冠肺炎的迅速传播每天都达到一个新的水平,迫切需要找到安全有效的措施来诊断、治疗、缓解和抗击这种疾病。鉴于这种疾病正在获得令人担忧的程度,正在调查不同药物系统之间的治疗策略。目前,临床管理包括感染预防、控制措施和支持性护理,包括补充氧气和必要时的机械通气。用于治疗新冠肺炎的药物干预措施包括人免疫球蛋白、干扰素、氯喹、羟氯喹、艾比隆、瑞德西韦、奥司他韦、法匹拉韦、卡霉素、甲基强的松龙、贝伐单抗、沙利度胺、维维他C、吡唑芬酮、达维韦、溴己酮、瑞沙韦、洛匹那韦、西延平和中药。但研究人员仍在努力寻找治疗当前新冠肺炎大流行的最有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Drug Candidates in Clinical Trials for the Treatment of Covid-19: An Updated Overview
The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, it spread to more than 200 countries worldwide. Particularly the USA, Brazil, Spain, Italy, France, Germany, UK, Turkey, Iran, and Russia were the most affected countries till December 2020. Currently, most of the researchers are in a continuous struggle to develop a vaccine or new drugs to combat Covid-19. There are more than 30 drug candidates including Western medicines, natural products, and traditional Chinese medicines, that have shown to exhibit some efficacy against this highly infectious virus. This review encompasses the potential efficacy of some key drugs recently tested against Covid-19. With the rapid spread of Covid-19 reaching a new level every day, there is an immediate need to find safe and effective measures to diagnose, treat, mitigate, and combat the disease. Looking at the alarming dimensions that the disease is acquiring, treatment strategies among the different drug systems are being investigated. Currently, clinical management includes infection prevention, control measures, and supportive care, including supplemental oxygen and mechanical ventilation when indicated. The pharmaceutical interventions evaluated for the treatment of Covid-19 include human immunoglobulin, interferons, chloroquine, hydroxychloroquine, arbidol, remdesivir, oseltamivir, favipiravir, carrimycin, methylprednisolone, bevacizumab, thalidomide, vitamin C, pyrodfenidone, darthviravir, bromexistone, ryrexavir, lopinavir, xiyanping, and traditional Chinese medicine. But still, the researchers are struggling to discover the most effective drug for the treatment of the current pandemic of Covid-19.
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来源期刊
Orbital: The Electronic Journal of Chemistry
Orbital: The Electronic Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
1.10
自引率
0.00%
发文量
25
审稿时长
10 weeks
期刊介绍: Orbital: The Electronic Journal of Chemistry is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Original contributions (in English) are welcome, which focus on all areas of Chemistry and their interfaces with Pharmacy, Biology, and Physics. Neither authors nor readers have to pay fees. The journal has an editorial team of scientists drawn from regions throughout Brazil and world, ensuring high standards for the texts published. The following categories are available for contributions: 1. Full papers 2. Reviews 3. Papers on Education 4. History of Chemistry 5. Short communications 6. Technical notes 7. Letters to the Editor The Orbital journal also publishes a number of special issues in addition to the regular ones. The central objectives of Orbital are threefold: (i) to provide the general scientific community (at regional, Brazilian, and worldwide levels) with a formal channel for the communication and dissemination of the Chemistry-related literature output by publishing original papers based on solid research and by reporting contributions which further knowledge in the field; (ii) to provide the community with open, free access to the full content of the journal, and (iii) to constitute a valuable channel for the dissemination of Chemistry-related investigations.
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