P. Gulbicka, Dagmara Pietkiewicz, Eliza Matuszewska, Szymon Plewa, Joanna Matysiak, M. Grzymisławski, Z. Kokot
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Evaluation of the proteomic profile in patients with celiac disease and malabsorption syndrome
The malabsorption syndrome includes many clinical units that lead to chronic diarrhea and malnutrition. In celiac disease and small intestine bacterial overgrowth making the diagnosis is not always straightforward, and the diagnosis often requires combining blood antibody tests, intestinal biopsies, and specific genetic testing. The study aimed to assess patients' protein/peptide profiles with celiac disease (n=31), small intestinal bacterial overgrowth (n=28), and the control group (n=30). Attempts have also been made to identify potential new diagnostic markers. After appropriate preparation, a proteomic analysis of peptides was performed using the MALDI–TOF mass spectrometer. Identified proteins were fibrinogen alpha-chain, kininogen-1, mucin 3A, complement C3, complement C4A, and inter-alpha-trypsin inhibitor heavy chain H4. Performed analyses indicated some proteins that could be potentially involved in the presence of the disease in question and proved that proteomic profiling might serve as a powerful diagnostic tool. Due to the difficulties in celiac disease and small intestine bacterial overgrowth diagnosis, there is a clear need for further investigation of the biological role of proteins potentially involved in the course of the disease.
期刊介绍:
The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General.
A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.