Cyathocalyx pruniferus（Maingay ex Hook.f.&Thomson）精油的化学成分和乙酰胆碱酯酶抑制作用J.Sinclair

Q3 Pharmacology, Toxicology and Pharmaceutics

Natural Volatiles and Essential Oils Pub Date : 2020-11-24 DOI:10.37929/nveo.770303

W. Salleh, S. Khamis, M. Nadri, Hakimi Kassim, A. Tawang

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引用次数: 1

摘要

首次研究了马来西亚彭亨地区春花叶挥发油的化学成分和乙酰胆碱酯酶抑制活性。采用加氢蒸馏的方法得到了该精油，并用气相色谱（GC）和气相色谱-质谱（GC-MS）对其进行了全面表征。从精油中成功鉴定出30种化学成分（95.53%），其特征是α-蒎烯（25.40%）、germacrene D（20.20%）、β-石竹烯（10.78%）和δ-cadinene（6.44%）的比例较高，精油对乙酰胆碱酯酶有良好的抑制作用（I:75.5%）。据我们所知，这是首次对Cyathocalyx属精油成分的研究。

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Chemical composition and acetylcholinesterase inhibition of the essential oil of Cyathocalyx pruniferus (Maingay ex Hook.f. & Thomson) J.Sinclair

The chemical composition and acetylcholinesterase inhibitory activity of the essential oil from the leaf of Cyathocalyx pruniferus growing in Pahang, Malaysia was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of thirty chemical components (95.53%) were successfully identified in the essential oil which was characterized by high proportions of α-pinene (25.40%), germacrene D (20.20%), β-caryophyllene (10.78%), and δ-cadinene (6.44%). Acetylcholinesterase inhibitory activity was evaluated against the Ellman method, and the essential oil showed good inhibition against acetylcholinesterase (I: 75.5%) assay. To the best of our knowledge, this is the first study of the composition of the essential oil report concerning the genus Cyathocalyx.

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来源期刊

Natural Volatiles and Essential Oils Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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