E. Handayani, D. Edianto, M. Sahil, L. Tobing, M. R. Yaznil
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引用次数: 1
摘要
背景谷胱甘肽过氧化物酶(GPx)是维持活性氧平衡的抗氧化酶之一。GPx在包括癌症在内的癌症的进展中具有显著作用。这种酶的合成可能在卵巢癌症的情况下被下调。据我们所知,这还没有在印度尼西亚人口中进行研究。目标。确定卵巢癌症患者和健康对照者血清GPx水平的差异。方法。这是一项采用病例对照设计的观察性分析研究。这项研究是在印度尼西亚棉兰Haji Adam Malik医院的妇产科进行的。对20例卵巢癌症患者和20例对照受试者的血清GPx水平进行了测定。结果。在本研究中,组织病理学鉴定的卵巢癌症类型包括浆液性腺癌(n=10;50%)和各种非癌性腺癌(50%)。癌症组血清GPx平均水平(295.235(244.479)mU/mL)显著低于对照组(743.546(131.949)mU/mL)(p 0.226)。发现卵巢癌症患者的血清GPx水平显著低于健康对照组。需要进一步的研究来确定该人群中卵巢癌症患者血清GPx的适当截止水平。
Glutathione peroxidase in ovarian cancer patients in Indonesia
Background . Glutathione peroxidase (GPx) is one of the antioxidant enzymes that maintain the balance of reactive oxygen species. GPx has a notable role in the progression of cancer, including ovarian cancer. Synthesis of this enzyme may be down-regulated in cases of ovarian cancer. As far as we are aware, this has not been studied in an Indonesian population. Objective. To identify the difference in serum GPx levels between ovarian cancer patients and healthy controls. Methods . This was an observational analytical study with a case–control design. The study was conducted in the Department of Obstetrics and Gynaecology at the Haji Adam Malik Hospital in Medan, Indonesia. Serum GPx levels were measured in 20 ovarian cancer patients and 20 control subjects. Results . The types of ovarian cancer identified by histopathology in this study included serous adenocarcinoma ( n =10; 50%) and various non-serous adenocarcinomas (50%). The mean (SD) serum GPx level was significantly lower in the cancer group (295.235 (244.479) mU/mL) than in the control group (743.546 (131.949) mU/mL) ( p 0.226). Conclusion . Serum GPx levels were found to be significantly lower in patients with ovarian cancer than in healthy controls. Further studies are needed to determine an appropriate cut-off level for serum GPx in ovarian cancer in this population.
期刊介绍:
The SAJOG is a tri-annual, general specialist obstetrics and gynaecology journal that publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. The journal carries original research articles, editorials, clinical practice, personal opinion, South Africa health-related news, obituaries and general correspondence.