内镜超声引导门静脉压力梯度测量:一项动物实验研究

中华消化内镜杂志 Pub Date : 2019-07-20 DOI:10.3760/CMA.J.ISSN.1007-5232.2019.07.010

Wei Zhang, Song Zhang, C. Peng, Feng Zhang, Guifang Xu, Ming Zhang, Xiao-liang Zhou, Lei Wang, Y. Zhuge, X. Zou

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引用次数: 0

摘要

目的评价内镜超声引导下在正常猪模型中门静脉压力梯度（EUS-PPG）测量的可行性和安全性。方法选择4头猪，雄性2头，雌性2头，年龄8-12个月，体重20-30公斤。在全身麻醉和EUS指导下，使用连接到带有中央静脉压力计的心电图监护仪的22G细针穿刺并测量门静脉（PV）、肝静脉（HV）或下腔静脉（IVC）的压力。每个容器的压力测量三次，并记录平均压力。PPG记录为PV压力与HV或IVC压力之间的差值。监测手术期间和手术后的生命体征以及与手术相关的并发症。结果EUS-PPG测量在所有靶血管中均获得成功。PV压力、HV或IVC压力和PPG分别为11.0±1.0 mmHg（1 mmHg=0.133 kPa）、7.3±1.1 mmHg和3.8±0.9 mmHg。未发生不良事件。结论EUS-PPG测量门静脉压力具有较高的成功率、可靠的准确性和安全性。关键词：腔内超声；高血压，门脉；入口压力梯度；肝静脉压力梯度

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Endoscopic ultrasound-guided portal pressure gradient measurement: a pilot animal study

Objective To evaluate the feasibility and safety of endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement in the normal porcine model. Methods Four pigs, 2 male and 2 female, aged 8-12 months, weighing 20-30 kg were selected in the experiment. Under general anesthesia and EUS guidance, a 22 G fine needle connected to electrocardiograph monitor with a central vein pressure manometer was used to puncture and measure pressures in the portal vein (PV) and hepatic vein (HV) or inferior vena cava (IVC). Pressures were measured three times for each vessel and the mean pressure was recorded. The PPG was recorded as the difference between the PV pressure and HV or IVC pressure. Vital signs during and after the procedure and operation-related complications were monitored. Results EUS-PPG measurement was successful in all targeted vessels. The PV pressure, HV or IVC pressure, and PPG was 11.0±1.0 mmHg(1 mmHg=0.133 kPa), 7.3±1.1 mmHg and 3.8±0.9 mmHg, respectively. No adverse event occurred. Conclusion EUS-PPG measurement has a high successful rate and reliable accuracy and safety reflecting the portal vein pressure. Key words: Endosonography; Hypertension, portal; Portal pressure gradient; Hepatic venous pressure gradient

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来源期刊

中华消化内镜杂志

CiteScore

0.10

自引率

0.00%

发文量

7555

期刊介绍： Chinese Journal of Digestive Endoscopy is a high-level medical academic journal specializing in digestive endoscopy, which was renamed Chinese Journal of Digestive Endoscopy in August 1996 from Endoscopy. Chinese Journal of Digestive Endoscopy mainly reports the leading scientific research results of esophagoscopy, gastroscopy, duodenoscopy, choledochoscopy, laparoscopy, colorectoscopy, small enteroscopy, sigmoidoscopy, etc. and the progress of their equipments and technologies at home and abroad, as well as the clinical diagnosis and treatment experience. The main columns are: treatises, abstracts of treatises, clinical reports, technical exchanges, special case reports and endoscopic complications. The target readers are digestive system diseases and digestive endoscopy workers who are engaged in medical treatment, teaching and scientific research. Chinese Journal of Digestive Endoscopy has been indexed by ISTIC, PKU, CSAD, WPRIM.